Home Journals Articles Updates About
CN
image
收藏切换
An exploration into mechanism of leukocyte elevation activity of Lvjiao Buxue granules based on network pharmacology
收藏切换
PDF
Lei YAN1, 2, Xiao-yan HE1, 2, Yao GAO1, 2, Huan XIANG3, Xiang-ping XU4, Sheng HUANG4, Dong-lan YAN4, Xue-mei QIN1, 2, Jun-sheng TIAN1, 2, 4, *
Acta Pharmaceutica Sinica | 2018, 53(10) : 1660 - 1669
Less
收藏切换
Acta Pharmaceutica Sinica | 2018, 53(10): 1660-1669
• ORIGINAL ARTICLES •
An exploration into mechanism of leukocyte elevation activity of Lvjiao Buxue granules based on network pharmacology
Full
Lei YAN1, 2, Xiao-yan HE1, 2, Yao GAO1, 2, Huan XIANG3, Xiang-ping XU4, Sheng HUANG4, Dong-lan YAN4, Xue-mei QIN1, 2, Jun-sheng TIAN1, 2, 4, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China
  • 3. School of Physical Education, Shanxi University, Taiyuan 030006, China
  • 4. Jiuzhitang Co. Ltd. Hunan, Changsha 410205, China
Published: 2018-10-12 doi: 10.16438/j.0513-4870.2018-0346
Outline
收藏切换

The mechanism of leukocyte elevation activity of Lvjiao Buxue granules was studied by establishing the active components-targets network and protein interactions network and analyzing the functions and pathways of targets. The main active ingredients of Lvjiao Buxue granules were obtained by TCMSP and literature excavation. Based on the DRAR-CPI, GeneCards and CoolGeN, the active components of Lvjiao Buxue granules were predicted and screened. Cytoscape software was used to construct the drug-active components-target network, and a protein database was constructed by using String database and Cytoscape software. The relation of the main active ingredients and targets were validated by Systems Dock Web Site. The GO and KEGG pathways involved in the targets were analyzed by DAVID databases. Using DisGeNET database to attribute the type of targets. The results showed that 49 active components and 89 targets of Lvjiao Buxue granules were involved. The network results showed that the composition of purine ribonucleosides, the regulation of cell death, especially the biological processes such as neutrophil and oxidative stress were mainly involved in the regulation of metabolic, cancer, tuberculosis, PI3K-Akt signaling and many other pathways to play its elevating leukocytes effect. This study reflects the characteristics of multi-components-multi-targets and multi-pathways of Lvjiao Buxue granules, which laid the foundation for further research into the mechanism of leukocyte elevation activity of Lvjiao Buxue granules.

Lvjiao Buxue granule  /  leucopenia  /  network pharmacology  /  molecular docking  /  protein interaction
Lei YAN, Xiao-yan HE, Yao GAO, Huan XIANG, Xiang-ping XU, Sheng HUANG, Dong-lan YAN, Xue-mei QIN, Jun-sheng TIAN. An exploration into mechanism of leukocyte elevation activity of Lvjiao Buxue granules based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (10) : 1660 -1669 . DOI: 10.16438/j.0513-4870.2018-0346
Appendix
Less
Year 2018 volume 53 Issue 10
PDF
156
62
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2018-0346
  • Receive Date：2018-04-16
  • Online Date：2026-01-15
  • Published：2018-10-12
Article Data
Affiliations
History
  • Received：2018-04-16
  • Revised：2018-06-01
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China
    3. School of Physical Education, Shanxi University, Taiyuan 030006, China
    4. Jiuzhitang Co. Ltd. Hunan, Changsha 410205, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2018-0346
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House