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Pharmacological mechanism of Compound Xueshuantong in treatment of diabetic retinopathy based on network pharmacology
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Yong-li SONG1, Zheng-lin WANG1, Wei XING1, Yan WU2, Wei WANG1, Jing HAN2, *
Acta Pharmaceutica Sinica | 2018, 53(9) : 1442 - 1448
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Acta Pharmaceutica Sinica | 2018, 53(9): 1442-1448
• SPECIAL REPORTS •
Pharmacological mechanism of Compound Xueshuantong in treatment of diabetic retinopathy based on network pharmacology
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Yong-li SONG1, Zheng-lin WANG1, Wei XING1, Yan WU2, Wei WANG1, Jing HAN2, *
Affiliations
  • 1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • 2. Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Published: 2018-09-15 doi: 10.16438/j.0513-4870.2018-0270
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The aim of this study was to discover the pharmacological mechanism of Compound Xueshuantong in the treatment of diabetic retinopathy using network pharmacology. TCMSP software was used to search the active ingredients of Compound Xueshuantong, and the targets of its active ingredients were obtained. The targets of diabetic retinopathy were searched by OMIM, TTD, pharmGkb, DiGSeE and GAD database. The same 37 targets were analyzed by GO and KEGG using DAVID software. The results were verified using the SystemsDock. Cytoscape 3.6.1 software was used to establish an ingredient-target-pathway network model. Network pharmacological studies suggest that Compound Xueshuantong treated diabetic retinopathy through the vascular endothelial growth factor signaling pathways, mitogen-activated protein kinase signaling pathways and Toll-like receptor signaling pathways. Compound Xueshuantong alleviated diabetic retinopathy through multi-component, multi-target, and multi-pathway. This study provides a theoretical basis for further elucidation of the pharmacological mechanism of Compound Xueshuantong in the treatment of diabetic retinopathy.

network pharmacology  /  Compound Xueshuantong  /  diabetic retinopathy  /  target
Yong-li SONG, Zheng-lin WANG, Wei XING, Yan WU, Wei WANG, Jing HAN. Pharmacological mechanism of Compound Xueshuantong in treatment of diabetic retinopathy based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (9) : 1442 -1448 . DOI: 10.16438/j.0513-4870.2018-0270
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Article Info
doi: 10.16438/j.0513-4870.2018-0270
  • Receive Date：2018-03-28
  • Online Date：2026-01-15
  • Published：2018-09-15
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  • Received：2018-03-28
  • Revised：2018-05-01
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    1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
    2. Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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