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Determination of ginkgolic acids in Yinxing Tongzhi Dropping Pills by mix-mode SPE-UHPLC/MS/MS
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Jian SUN1, Xue-yi ZHANG2, Li-min LI1, Qing HU1, Yan-rong ZHU1, Xiu-hong MAO1, Shen JI1, *
Acta Pharmaceutica Sinica | 2018, 53(9) : 1532 - 1535
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Acta Pharmaceutica Sinica | 2018, 53(9): 1532-1535
• ORIGINAL ARTICLES •
Determination of ginkgolic acids in Yinxing Tongzhi Dropping Pills by mix-mode SPE-UHPLC/MS/MS
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Jian SUN1, Xue-yi ZHANG2, Li-min LI1, Qing HU1, Yan-rong ZHU1, Xiu-hong MAO1, Shen JI1, *
Affiliations
  • 1. Shanghai Institute for Food and Drug Control, Shanghai 201203, China
  • 2. Shanghai Shangyao Xingling Technology Pharmaceutical Co., Ltd., Shanghai 201703, China
Published: 2018-09-12 doi: 10.16438/j.0513-4870.2018-0248
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An analytical method was developed for determination of ginkgolic acids in Yinxing Tongzhi Dropping Pills by ultra high performance liquid chromatography-triple quadrupole mass spectrometry. The samples were purified by mix-mode anion exchange and reversed-phase SPE. A chromatographic column, Waters Cortecs T3 (50 mm×2.1 mm, 2.7 μm), was used with acetonitrile-methanol-1% acetic acid (44:44:12) as the mobile phase. The ginkgolic acids were detected by electrospray ionization mass spectrometry in negative mode with multiple reaction monitoring (MRM) mode. Ginkgolic acid C13:0, C15:1 and C17:1 possessed good linear correlation in the mass concentration range from 0.2 to 200 μg·L-1, 2 to 200 μg·L-1, 4 to 200 μg·L-1, respectively, with the correlation coefficients more than 0.999. The mean recoveries at spiked levels of 50, 250 and 600 μg·kg-1 were in the range of 70.8%-95.1%, and the RSDs were 0.7%-8.6%. The limits of quantification were 1, 10, 20 μg·kg-1, respectively. The method could be applied to the analysis of ginkgolic acids in complex matrix samples.

ultra high performance liquid chromatography-tandem mass spectrometry  /  mix-mode solidphase extraction  /  ginkgolic acid  /  Yinxing Tongzhi Dropping Pills
Jian SUN, Xue-yi ZHANG, Li-min LI, Qing HU, Yan-rong ZHU, Xiu-hong MAO, Shen JI. Determination of ginkgolic acids in Yinxing Tongzhi Dropping Pills by mix-mode SPE-UHPLC/MS/MS[J]. Acta Pharmaceutica Sinica, 2018 , 53 (9) : 1532 -1535 . DOI: 10.16438/j.0513-4870.2018-0248
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Year 2018 volume 53 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2018-0248
  • Receive Date：2018-03-21
  • Online Date：2026-01-15
  • Published：2018-09-12
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History
  • Received：2018-03-21
  • Revised：2018-05-04
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Affiliations
    1. Shanghai Institute for Food and Drug Control, Shanghai 201203, China
    2. Shanghai Shangyao Xingling Technology Pharmaceutical Co., Ltd., Shanghai 201703, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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