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Cytoprotective effect of p62/Nrf2 signaling pathway
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Xiao-hua LI1, Nai-fu TANG1, Yong-qiang LI2, *, Bin LIU1, *
Acta Pharmaceutica Sinica | 2018, 53(12) : 1995 - 2005
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Acta Pharmaceutica Sinica | 2018, 53(12): 1995-2005
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Cytoprotective effect of p62/Nrf2 signaling pathway
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Xiao-hua LI1, Nai-fu TANG1, Yong-qiang LI2, *, Bin LIU1, *
Affiliations
  • 1. Institute of Nursing and Health, Henan University, Kaifeng 475004, China
  • 2. School of Basic Medical Science, Henan University, Kaifeng 475004, China
Published: 2018-12-12 doi: 10.16438/j.0513-4870.2018-0149
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The Nrf2-Keap1-ARE pathway is an important signaling axis that functions to protect cells against oxidative stress and harmful chemicals through the induction of cytoprotective genes. The maintenance and protective role of Nrf2 pathway has been recognized as a means for chemoprevention. On the other hand, constitutive activation of Nrf2, due to somatic mutations of genes that control Nrf2 degradation, promotes carcinogenesis and imparts chemoresistance to cancer cells. Autophagy is another tightly regulated complex cellular process that functions as a cellular quality control system to remove damaged proteins or organelles. Recently, these two cellular pathways were shown to intersect through the direct interaction between p62 (an autophagy adaptor protein) and Keap1. Dysregulation of autophagy was shown to result in prolonged activation of Nrf2 in a p62-dependent manner, which is associated with the pathogenesis and therapies of several human diseases including cancer. In this review, we discuss the molecular mechanisms of p62-mediated Nrf2 signaling pathway, with a special emphasis on their impact on nervous system disease, cardiovascular disease and cancer.

p62  /  oxidative stress  /  nuclear factor erythroid 2-related factor 2  /  Keap1  /  autophagy  /  cytoprotection
Xiao-hua LI, Nai-fu TANG, Yong-qiang LI, Bin LIU. Cytoprotective effect of p62/Nrf2 signaling pathway[J]. Acta Pharmaceutica Sinica, 2018 , 53 (12) : 1995 -2005 . DOI: 10.16438/j.0513-4870.2018-0149
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doi: 10.16438/j.0513-4870.2018-0149
  • Receive Date：2018-08-03
  • Online Date：2026-01-15
  • Published：2018-12-12
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  • Received：2018-08-03
  • Revised：2018-09-20
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    1. Institute of Nursing and Health, Henan University, Kaifeng 475004, China
    2. School of Basic Medical Science, Henan University, Kaifeng 475004, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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