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Effect of neural stem cell niche in neurogenesis
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Shan WANG1, Ping-ping LI2, Xiao-liang WANG1, *, Ying PENG1, *
Acta Pharmaceutica Sinica | 2018, 53(5) : 684 - 690
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Acta Pharmaceutica Sinica | 2018, 53(5): 684-690
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Effect of neural stem cell niche in neurogenesis
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Shan WANG1, Ping-ping LI2, Xiao-liang WANG1, *, Ying PENG1, *
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. China National Center for Biotechnology Development, Beijing 100039, China
Published: 2018-05-12 doi: 10.16438/j.0513-4870.2018-0071
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Neural stem cell is a cell type with the ability of self-renewing and the potential to differentiate into neurons, astrocytes or oligodendrocytes. Neurogenesis is beneficial for the recovery of many neurological diseases, such as stroke, Alzheimer's disease and so on. Neurogenesis capacity can maintain through the whole life, which includes the proliferation, migration and differentiation of neural stem cell, as well as the incorporation into the neuronal network of newborn neurons. The self-renewal and differentiation activities of neural stem cell are regulated by the microenvironment, which is defined as neural stem cell niche. Components of neural stem cell niche include cell-cell interactions, cytokines, extracellular matrix and vascular niche. Illustration of neural stem cell niche impact is far more significant for the treatment of certain nervous system diseases. This review summarizes the current understanding of the relationship between neural stem cell niche and the fate of neural stem cell.

niche  /  neurogenesis  /  neural stem cell  /  cytokines  /  extracellular matrix
Shan WANG, Ping-ping LI, Xiao-liang WANG, Ying PENG. Effect of neural stem cell niche in neurogenesis[J]. Acta Pharmaceutica Sinica, 2018 , 53 (5) : 684 -690 . DOI: 10.16438/j.0513-4870.2018-0071
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Article Info
doi: 10.16438/j.0513-4870.2018-0071
  • Receive Date：2018-01-17
  • Online Date：2026-01-15
  • Published：2018-05-12
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  • Received：2018-01-17
  • Revised：2018-02-13
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    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. China National Center for Biotechnology Development, Beijing 100039, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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