Home Journals Articles Updates About
CN
image
收藏切换
Complicated intermolecular interactions formed between organofluorine and drug target
收藏切换
PDF
Gui-min WANG1, 2, Zheng-dan ZHU1, 2, Zhao-qiang CHEN1, Zhi-jian XU1, Wei-liang ZHU1, 2, *
Acta Pharmaceutica Sinica | 2018, 53(5) : 701 - 708
Less
收藏切换
Acta Pharmaceutica Sinica | 2018, 53(5): 701-708
• REVIEWS •
Complicated intermolecular interactions formed between organofluorine and drug target
Full
Gui-min WANG1, 2, Zheng-dan ZHU1, 2, Zhao-qiang CHEN1, Zhi-jian XU1, Wei-liang ZHU1, 2, *
Affiliations
  • 1. CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 2. University of Chinese Academy of Sciences, Beijing 100049, China
Published: 2018-05-12 doi: 10.16438/j.0513-4870.2018-0013
Outline
收藏切换

Fluorinated compounds, which now make up 20%-25% of all marketed chemical drugs, are playing significant role and showing great potential in medicinal chemistry. Fluorine substitution is always utilized to change the physicochemical properties of the compounds to improve the ADME/T properties. In addition, fluorine substitution leads to improvement of the ligand binding affinity. With respect to molecular level, organofluorine can form various intermolecular interactions with the target proteins, e.g., hydrogen bond, halogen bond, C-F…π interaction, polar interaction and so on. These interactions display unique properties or nature due to the specificity of fluorine atom, which are at the center of attention. This paper reviews the related research background, followed by the research progress of hydrogen bond, halogen bond, C-F…π interaction, polar interaction and some other interactions involved organofluorine.

organofluorine  /  weak intermolecular interaction  /  hydrogen bond  /  halogen bond  /  C-F…π interaction
Gui-min WANG, Zheng-dan ZHU, Zhao-qiang CHEN, Zhi-jian XU, Wei-liang ZHU. Complicated intermolecular interactions formed between organofluorine and drug target[J]. Acta Pharmaceutica Sinica, 2018 , 53 (5) : 701 -708 . DOI: 10.16438/j.0513-4870.2018-0013
Appendix
Less
Year 2018 volume 53 Issue 5
PDF
144
47
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2018-0013
  • Receive Date：2018-01-04
  • Online Date：2026-01-15
  • Published：2018-05-12
Article Data
Affiliations
History
  • Received：2018-01-04
  • Revised：2018-01-23
Funding
Affiliations
    1. CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    2. University of Chinese Academy of Sciences, Beijing 100049, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2018-0013
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House