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1H NMR-based metabolomics analysis of the anti-fatigue effects of Astragali Radix based on muscle tissue Pubescentis
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Rui ZHANG1, 2, 3, 4, Ke LI1, 3, 4, *, Ai-ping LI1, 3, 4, Yue-tao LIU1, 3, 4, Xue-mei QIN1, 3, 4, *, Xiang ZHANG5, Guan-hua DU6
Acta Pharmaceutica Sinica | 2018, 53(5) : 782 - 790
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Acta Pharmaceutica Sinica | 2018, 53(5): 782-790
• ORIGINAL ARTICLES·Pharmaceutical Analysis •
1H NMR-based metabolomics analysis of the anti-fatigue effects of Astragali Radix based on muscle tissue Pubescentis
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Rui ZHANG1, 2, 3, 4, Ke LI1, 3, 4, *, Ai-ping LI1, 3, 4, Yue-tao LIU1, 3, 4, Xue-mei QIN1, 3, 4, *, Xiang ZHANG5, Guan-hua DU6
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Shanxi University, Taiyuan 030006, China
  • 4. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
  • 5. Medical College, University of Louisville, Louisville 40292, USA
  • 6. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2018-05-12 doi: 10.16438/j.0513-4870.2017-1289
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This study was designed to explore the intervention of muscle fatigue in rats with Astragali Radix using 1H NMR metabolomics methods. The fatigue model was induced in rats by forced swimming plus food restriction, and the effects of Astragali Radix (3, 6 and 12 g·kg-1) were investigated using the exhaustive time of rat swimming. After 3 weeks, the gastrocnemius was collected for 1H NMR detection, and the anti-fatigue effects of Astragali Radix were explored using multivariate statistical analysis. Astragali Radix significantly improved the exhaustive swimming time of rats. Compared with control group, the levels of isoleucine, leucine, creatine, phosphatidylcholine, trimethylamine oxide, taurine, guanidinoacetate, AMP, inosine, histidine, hypoxanthine, anserine in rat gastrocnemius of model group were increased. While the levels of lactate, acetone, choline, glycerophosphocholine, glycine were decreased. These 6, 11, 5 potential biomarkers could be reversely regulated by treatment with Astragali Radix (high dose, middle dose, low dose), respectively. Metabolomics analysis revealed that Astragali Radix has a certain anti-fatigue effects and the mechanism may be related to regulation of amino metabolism.

Astragali Radix  /  anti-fatigue  /  muscle  /  metabonomics  /  amino metabolism
Rui ZHANG, Ke LI, Ai-ping LI, Yue-tao LIU, Xue-mei QIN, Xiang ZHANG, Guan-hua DU. 1H NMR-based metabolomics analysis of the anti-fatigue effects of Astragali Radix based on muscle tissue Pubescentis[J]. Acta Pharmaceutica Sinica, 2018 , 53 (5) : 782 -790 . DOI: 10.16438/j.0513-4870.2017-1289
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Article Info
doi: 10.16438/j.0513-4870.2017-1289
  • Receive Date：2017-12-25
  • Online Date：2026-01-15
  • Published：2018-05-12
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  • Received：2017-12-25
  • Revised：2018-01-29
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Shanxi University, Taiyuan 030006, China
    4. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
    5. Medical College, University of Louisville, Louisville 40292, USA
    6. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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