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Identification of chemical constituents in Naozhenning granule by UHPLC coupled with hybrid quadrupole-orbitrap MS
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Shu-ting YU1, 3, Hai-xia LIU2, Kun LI2, Zheng-guo QIN2, Xue-mei QIN1, Ping ZHU2, *, Zhen-yu LI1, *
Acta Pharmaceutica Sinica | 2018, 53(4) : 609 - 620
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Acta Pharmaceutica Sinica | 2018, 53(4): 609-620
• ORIGINAL ARTICLES·Pharmaceutical Analysis •
Identification of chemical constituents in Naozhenning granule by UHPLC coupled with hybrid quadrupole-orbitrap MS
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Shu-ting YU1, 3, Hai-xia LIU2, Kun LI2, Zheng-guo QIN2, Xue-mei QIN1, Ping ZHU2, *, Zhen-yu LI1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, China
  • 2. Shanxi Zhendong Ante Biological Pharmaceutical Co., Ltd., Jinzhong 030600, China
  • 3. College of Chemistry and Chemical Engineering of Shanxi University, Taiyuan 030006, China
Published: 2018-04-12 doi: 10.16438/j.0513-4870.2017-1190
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Naozhenning granule, which is composed of 11 herbal drugs, is mainly used in the treatment of concussion, cerebral post-traumatic syndrome. As the chemical composition of Naozhenning was complex, the ultrahigh performance liquid chromatography coupled with hybrid quadrupole-orbitrap mass spectrometry was applied to identify the chemical constituents rapidly in the Naozhenning granule. By analyzing the retention behaviors, accurate molecular weight, the fragmentation pathway, and comparison with the MS data from the standards and references, as well as the automatic identification by the Compound Discover 2.0, a total of 161 compounds were identified or tentatively deduced, and the sources of constituents were also confirmed. The compounds identified in Naozhenning granule included 9 iridoids, 8 butylphthalides, 26 flavonoids and flavonoid glycosides, 8 phenolic acids, 8 monoterpenoid glycosides and 9 alkaloids, as well as the common compounds in the herbal drugs, such as organic acids, amino acids, and sugars. The chemical composition of Naozhenning was studied for the first time, which provides a scientific basis for the quality control and document of effective materials of Naozhenning granule.

Naozhenning granule  /  chemical constituent  /  UHPLC-Q Exactive quadrupole-orbitrap MS
Shu-ting YU, Hai-xia LIU, Kun LI, Zheng-guo QIN, Xue-mei QIN, Ping ZHU, Zhen-yu LI. Identification of chemical constituents in Naozhenning granule by UHPLC coupled with hybrid quadrupole-orbitrap MS[J]. Acta Pharmaceutica Sinica, 2018 , 53 (4) : 609 -620 . DOI: 10.16438/j.0513-4870.2017-1190
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Article Info
doi: 10.16438/j.0513-4870.2017-1190
  • Receive Date：2017-11-30
  • Online Date：2026-01-15
  • Published：2018-04-12
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  • Received：2017-11-30
  • Revised：2018-01-10
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, China
    2. Shanxi Zhendong Ante Biological Pharmaceutical Co., Ltd., Jinzhong 030600, China
    3. College of Chemistry and Chemical Engineering of Shanxi University, Taiyuan 030006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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