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Mechanism of anti-hepatitis B virus activity of Tonkinensis based on biological targets network
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Xuan CHAI1, 2, 3, Ya-kun MENG2, Zhao-fang BAI2, Ya-ming ZHANG2, Xiao-he XIAO2, *, Ming NIU2, *
Acta Pharmaceutica Sinica | 2018, 53(3) : 396 - 402
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Acta Pharmaceutica Sinica | 2018, 53(3): 396-402
• ORIGINAL ARTICLES·Pharmacology •
Mechanism of anti-hepatitis B virus activity of Tonkinensis based on biological targets network
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Xuan CHAI1, 2, 3, Ya-kun MENG2, Zhao-fang BAI2, Ya-ming ZHANG2, Xiao-he XIAO2, *, Ming NIU2, *
Affiliations
  • 1. Academy of Military Medical Sciences, Beijing 100850, China
  • 2. China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China
  • 3. The 3th Hospital of Chinese Armed Police Force in Beijing, Be ijing 100141, China
Published: 2018-03-12 doi: 10.16438/j.0513-4870.2017-1124
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Tonkinensis is commonly used in the treatment of hepatitis B infection in China with its effecttiveness in reducing clinical symptoms and improving liver function. However, the mechanism of the anti-HBV (hepatitis B virus) effect of Tonkinensis is still not clear. In this study, an integrative analysis using the network pharmacology and metabolomics was employed in identification of the main targets and mechanisms of Tonkinensis in treatment of HBV infections. First, the "drug-target" network was established by predicting the targets of the main chemical components of Tonkinensis; Secondly, the differential metabolites associated with the anti-HBV effect of Tonkinensis were analyzed with the LC-MS based metabolomics in HepG2.2.15 cells; Finally, the "drug ingredients-targets-metabolites" network was constructed to screen the main anti-HBV targets of Tonkinensis. The results suggest that Tonkinensis may act on 16 target proteins in the network of retinol metabolism, peroxisome proliferator activate-receptors (PPAR) signaling pathway and transcriptional regulation of cancer and so on, which contributed to the control of HBV replication and the regulation of immune function and metabolic disorders.

Tonkinensis  /  network pharmacology  /  metabolomics  /  hepatitis B virus
Xuan CHAI, Ya-kun MENG, Zhao-fang BAI, Ya-ming ZHANG, Xiao-he XIAO, Ming NIU. Mechanism of anti-hepatitis B virus activity of Tonkinensis based on biological targets network[J]. Acta Pharmaceutica Sinica, 2018 , 53 (3) : 396 -402 . DOI: 10.16438/j.0513-4870.2017-1124
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Article Info
doi: 10.16438/j.0513-4870.2017-1124
  • Receive Date：2017-11-14
  • Online Date：2026-01-15
  • Published：2018-03-12
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History
  • Received：2017-11-14
  • Revised：2018-01-12
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Affiliations
    1. Academy of Military Medical Sciences, Beijing 100850, China
    2. China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China
    3. The 3th Hospital of Chinese Armed Police Force in Beijing, Be ijing 100141, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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