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Short term high-fat diet feeding alleviates the cognitive impairment induced by okada acid injection in rats
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Tian-bi ZHU1, 2, Zhao ZHANG2, Piao LUO1, 2, Shi-feng CHU2, Nai-hong CHEN1, 2, *
Acta Pharmaceutica Sinica | 2018, 53(3) : 383 - 387
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Acta Pharmaceutica Sinica | 2018, 53(3): 383-387
• ORIGINAL ARTICLES·Pharmacology •
Short term high-fat diet feeding alleviates the cognitive impairment induced by okada acid injection in rats
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Tian-bi ZHU1, 2, Zhao ZHANG2, Piao LUO1, 2, Shi-feng CHU2, Nai-hong CHEN1, 2, *
Affiliations
  • 1. College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
  • 2. Neuroscience Center, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, China
Published: 2018-03-12 doi: 10.16438/j.0513-4870.2017-1009
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This study was designed to test the effect of short-term high-fat diet feeding on the cognitive impairment in a rat model of Alzheimer's disease. After establishment of Alzheimer's disease model, the rats were fed on a high-fat diet, and subjected to water maze (Morris water maze, MWM) behavioral test for learning and memory ability. Western blot was used to detect the expression of caspase-1 pathway. The results showed that short-term high-fat diet could alleviate the damage of okada acid in Morris water maze. The mechanism may be mediated by the regulation of the NLRP3/caspase-1 signaling pathway, which alleviates neuronal damage, resulting in a protective effect.

Alzheimer's disease  /  okada acid  /  high fat diet  /  neuroprotection  /  inflammasome
Tian-bi ZHU, Zhao ZHANG, Piao LUO, Shi-feng CHU, Nai-hong CHEN. Short term high-fat diet feeding alleviates the cognitive impairment induced by okada acid injection in rats[J]. Acta Pharmaceutica Sinica, 2018 , 53 (3) : 383 -387 . DOI: 10.16438/j.0513-4870.2017-1009
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Article Info
doi: 10.16438/j.0513-4870.2017-1009
  • Receive Date：2017-10-16
  • Online Date：2026-01-15
  • Published：2018-03-12
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  • Received：2017-10-16
  • Revised：2017-11-20
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    1. College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
    2. Neuroscience Center, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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