Home Journals Articles Updates About
CN
image
收藏切换
Development of decision system for individualization of vancomycin dosage
收藏切换
PDF
Yu-cheng GAO1, Zheng JIAO1, *, Hong HUANG2, Chen XIE3, Jian-jun GAO3, Liang ZHANG1, Jie FANG4, Wei-wei LIN5, Yi-xi LIU1, 6, Ye GONG7
Acta Pharmaceutica Sinica | 2018, 53(1) : 104 - 110
Less
收藏切换
Acta Pharmaceutica Sinica | 2018, 53(1): 104-110
• ORIGINAL ARTICLES •
Development of decision system for individualization of vancomycin dosage
Full
Yu-cheng GAO1, Zheng JIAO1, *, Hong HUANG2, Chen XIE3, Jian-jun GAO3, Liang ZHANG1, Jie FANG4, Wei-wei LIN5, Yi-xi LIU1, 6, Ye GONG7
Affiliations
  • 1. Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040, China
  • 2. Department of Medical Information, Huashan Hospital, Fudan University, Shanghai 200040, China
  • 3. Microsoft Corporation, Shanghai 200030, China
  • 4. Department of Pharmacy, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • 5. Department of Pharmacy, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
  • 6. School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China
  • 7. Department of Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
Published: 2018-01-12 doi: 10.16438/j.0513-4870.2017-0673
Outline
收藏切换

Vancomycin has been widely prescribed as the first-line antibiotic in the treatment of methicillin-resistant Staphylococcus aureus and other serious Gram-positive infections. Due to its large pharmacokinetic (PK) variability and narrow therapeutic range, it requires optimization of dosage to achieve target exposure. In this study, SmartDose, a decision support system for individualization of vancomycin dosage is developed using the maximum a posterior Bayesian estimation (MAPB) by the open-source language R combined with the population PK characteristics of vancomycin in Chinese patients. It provides initial design and adjustment of dose regimens based on the therapeutic drug monitoring (TDM) results, as well as a user-defined module to facilitate optimal vancomycin therapy. SmartDose has a high computational reliability, which is validated by NONMEM, the golden standard PK software. Meanwhile, SmartDose is established as a web-based application and its operational flexibility makes it an efficient tool for vancomycin dose optimization in routine clinical settings.

vancomycin  /  dose individualization  /  decision support system  /  population pharmacokinetic  /  maximum a posteriori Bayesian estimation
Yu-cheng GAO, Zheng JIAO, Hong HUANG, Chen XIE, Jian-jun GAO, Liang ZHANG, Jie FANG, Wei-wei LIN, Yi-xi LIU, Ye GONG. Development of decision system for individualization of vancomycin dosage[J]. Acta Pharmaceutica Sinica, 2018 , 53 (1) : 104 -110 . DOI: 10.16438/j.0513-4870.2017-0673
Appendix
Less
Year 2018 volume 53 Issue 1
PDF
146
60
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2017-0673
  • Receive Date：2017-07-11
  • Online Date：2026-01-15
  • Published：2018-01-12
Article Data
Affiliations
History
  • Received：2017-07-11
  • Revised：2017-10-01
Funding
Affiliations
    1. Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040, China
    2. Department of Medical Information, Huashan Hospital, Fudan University, Shanghai 200040, China
    3. Microsoft Corporation, Shanghai 200030, China
    4. Department of Pharmacy, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    5. Department of Pharmacy, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
    6. School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China
    7. Department of Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2017-0673
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House