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Research advances in brain monoamine neurotransmitters in the aging-associated memory decline
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Jia-qi LI1, 2, Li GAO1, *, Yu-zhi ZHOU1, Xue-mei QIN1, Guan-hua DU3, *
Acta Pharmaceutica Sinica | 2017, 52(11) : 1639 - 1646
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Acta Pharmaceutica Sinica | 2017, 52(11): 1639-1646
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Research advances in brain monoamine neurotransmitters in the aging-associated memory decline
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Jia-qi LI1, 2, Li GAO1, *, Yu-zhi ZHOU1, Xue-mei QIN1, Guan-hua DU3, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2017-11-12 doi: 10.16438/j.0513-4870.2017-0471
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Learning and memory decline is an important manifestation of aging, seriously affecting the health and life quality of the elderly. Aging-related learning and memory decline is often accompanied by decreased levels of norepinephrine, dopamine and serotonin neurotransmitters in the relevant brain regions. Monoamine neurotransmitters in different brain regions bind to receptors and regulate synaptic plasticity, which play an important role in learning and memory. This article reviews the changes of monoamine neurotransmitters in different brain regions, the mechanisms in regulation of learning and memory, and the factors causing abnormal levels of neurotransmitters in the process of aging in order to better understand the mechanisms of senile learning and memory decline to facilitate drug research.

aging  /  learning and memory  /  monoamine neurotransmiter  /  synaptic plasticity  /  long-term potentiation
Jia-qi LI, Li GAO, Yu-zhi ZHOU, Xue-mei QIN, Guan-hua DU. Research advances in brain monoamine neurotransmitters in the aging-associated memory decline[J]. Acta Pharmaceutica Sinica, 2017 , 52 (11) : 1639 -1646 . DOI: 10.16438/j.0513-4870.2017-0471
Year 2017 volume 52 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2017-0471
  • Receive Date:2017-05-11
  • Online Date:2026-01-14
  • Published:2017-11-12
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History
  • Received:2017-05-11
  • Revised:2017-06-09
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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