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Construction and evaluation of charge-reversal nanocarrier loaded with hematoporphyrin monomethyl ether
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Ai-ren XU1, Jian-hui RONG1, Meng-jia CHEN1, Zheng-hong FENG1, Wei-cheng MA1, *, Song SHEN3, Yi JIN2
Acta Pharmaceutica Sinica | 2017, 52(10) : 1605 - 1610
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Acta Pharmaceutica Sinica | 2017, 52(10): 1605-1610
• ORIGINAL ARTICLES •
Construction and evaluation of charge-reversal nanocarrier loaded with hematoporphyrin monomethyl ether
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Ai-ren XU1, Jian-hui RONG1, Meng-jia CHEN1, Zheng-hong FENG1, Wei-cheng MA1, *, Song SHEN3, Yi JIN2
Affiliations
  • 1. Ningbo Urinary and Renal Diseases Hospital, Ningbo 315100, China
  • 2. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
  • 3. School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
Published: 2017-10-12 doi: 10.16438/j.0513-4870.2017-0431
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Charge-reversal nanocarrier was constructed to enhance lysosomal escape and improve an-titumor effect. We synthesized the cholesterol-polyethyleneimine-hexahydrophthalic anhydride (Chol-PEI-HHPA) polymer and characterized by 1H NMR. The charge-reversal liposomes (Lipo-HHPA) were synthesized and the hematoporphyrin monomethyl ether (HMME) was loaded. pH-triggered charge conversion was determined at different pH values. The lysosomal escape and cytotoxicity of the Lipo-HHPA were evaluated in MCF-7 cells. The Lipo-HHPA was uniform with an average particle size of 102 nm. Upon the irradiation of ultrasound, burst release of HMME could be observed. The zeta potential of Lipo-HHPA changed sharply from negative (-23.5 mV) to positive (+21.2 mV) over the pH range of 7.4-4.5. In the cellular uptake experiment, the lysosomal escape of Lipo-HHPA was observed. HMME loaded Lipo-HHPA displayed obviously enhanced cytotoxicity towards MCF-7 cells. These results indicate that the charge-reversal liposomes hold a great potential in improving the cytotoxicity and antitumor effect.

charge conversion  /  lysosomal escape  /  hematoporphyrin monomethyl ether  /  sonodynamic therapy  /  targeted delivery
Ai-ren XU, Jian-hui RONG, Meng-jia CHEN, Zheng-hong FENG, Wei-cheng MA, Song SHEN, Yi JIN. Construction and evaluation of charge-reversal nanocarrier loaded with hematoporphyrin monomethyl ether[J]. Acta Pharmaceutica Sinica, 2017 , 52 (10) : 1605 -1610 . DOI: 10.16438/j.0513-4870.2017-0431
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Year 2017 volume 52 Issue 10
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Article Info
doi: 10.16438/j.0513-4870.2017-0431
  • Receive Date：2017-05-02
  • Online Date：2026-01-14
  • Published：2017-10-12
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History
  • Received：2017-05-02
  • Revised：2017-06-13
Funding
Affiliations
    1. Ningbo Urinary and Renal Diseases Hospital, Ningbo 315100, China
    2. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
    3. School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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