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A new pyrazine derivative from Dioscorea opposite Thunb.
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Wei-sheng FENG1, 2, *, Fang LI1, 2, Meng-huan GUO1, 2, Yan-gang CAO1, 3, Yan-yun YANG1, 2, Wen-jing CHEN1, 2, Man QI1, 2, Xiao-lan WANG1, Xiao-ke ZHENG1, 2
Acta Pharmaceutica Sinica | 2017, 52(8) : 1299 - 1301
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Acta Pharmaceutica Sinica | 2017, 52(8): 1299-1301
• ORIGINAL ARTICLES Medicinal Chemistry •
A new pyrazine derivative from Dioscorea opposite Thunb.
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Wei-sheng FENG1, 2, *, Fang LI1, 2, Meng-huan GUO1, 2, Yan-gang CAO1, 3, Yan-yun YANG1, 2, Wen-jing CHEN1, 2, Man QI1, 2, Xiao-lan WANG1, Xiao-ke ZHENG1, 2
Affiliations
  • 1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
  • 3. College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
Published: 2017-08-12 doi: 10.16438/j.0513-4870.2017-0245
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The chemical constituents of Dioscorea opposite Thunb. were isolated and purified by Diaion HP-20, Sephadex LH-20, Toyopearl HW-40, MCI Gel CHP-20, ODS, silica gel column chromatography and semi-preparative-HPLC. Nine compounds were found and their structures were elucidated by spectral data and physicochemical properties, which were identified as 2-(1', 2', 3'-trihydroxybutyl-4'-O-α-D-glucopyranoside)-6-(2", 3", 4"-trihydroxybutyl)-pyrazine (1), uracil (2), xanthine (3), hypoxanthine (4), thymine (5), adenosine (6), uridine (7), inosine (8), and 5'-deoxy-5'-methylsulphinyladenosine (9). The compound 1 is a new pyrazine derivative, and the compound 3-5, 8, 9 are found in this plant for the first time.

Dioscorea opposite  /  chemical constituent  /  pyrazine derivative  /  nucleosides
Wei-sheng FENG, Fang LI, Meng-huan GUO, Yan-gang CAO, Yan-yun YANG, Wen-jing CHEN, Man QI, Xiao-lan WANG, Xiao-ke ZHENG. A new pyrazine derivative from Dioscorea opposite Thunb.[J]. Acta Pharmaceutica Sinica, 2017 , 52 (8) : 1299 -1301 . DOI: 10.16438/j.0513-4870.2017-0245
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Article Info
doi: 10.16438/j.0513-4870.2017-0245
  • Receive Date：2017-03-22
  • Online Date：2026-01-14
  • Published：2017-08-12
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  • Received：2017-03-22
  • Revised：2017-03-29
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Affiliations
    1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
    3. College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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