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Role of FMOs in drug metabolism and development
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Ya-kun YANG, Li SHENG, Yan LI*
Acta Pharmaceutica Sinica | 2017, 52(10) : 1485 - 1495
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Acta Pharmaceutica Sinica | 2017, 52(10): 1485-1495
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Role of FMOs in drug metabolism and development
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Ya-kun YANG, Li SHENG, Yan LI*
Affiliations
  • Department of Drug Metabolism, Beijing City Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Beijing City Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2017-10-12 doi: 10.16438/j.0513-4870.2017-0231
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The flavin-containing monooxygenase (FMOs) is recognized as an important complimentary enzyme system next to the cytochrome P450 (CYP450), which catalyzes the metabolism of many xenobiotics (nucleophilic heteroatom-containing chemicals) and several endobiotics. This article provides a comprehensive introduction of FMOs including the biological characteristics, catalytic mechanism, substrate specificity, genetic polymorphisms. The effect of FMOs on drug metabolism and individual differences and relation with diseases are also mentioned. It is valuable for the discovery of therapeutic targets and design of new drug candidate.

flavin-containing monooxygenase  /  cytochrome P450  /  gene polymorphism  /  individual differ-ence  /  drug metabolism  /  new drug development
Ya-kun YANG, Li SHENG, Yan LI. Role of FMOs in drug metabolism and development[J]. Acta Pharmaceutica Sinica, 2017 , 52 (10) : 1485 -1495 . DOI: 10.16438/j.0513-4870.2017-0231
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Article Info
doi: 10.16438/j.0513-4870.2017-0231
  • Receive Date：2017-03-30
  • Online Date：2026-01-14
  • Published：2017-10-12
Article Data
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History
  • Received：2017-03-30
  • Revised：2017-06-09
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Affiliations
    Department of Drug Metabolism, Beijing City Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Beijing City Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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