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Network pharmacology-based study on intervention mechanism of Huanglian Jiedu decoction in the treatment of Alzheimer's disease
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Li-min SUN1, 2, 3, Li-fang LIU1, *, Hua-xu ZHU2, 3, *, Bao-jie ZHU2, 3, Qi-chun ZHANG2, 3
Acta Pharmaceutica Sinica | 2017, 52(8) : 1268 - 1275
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Acta Pharmaceutica Sinica | 2017, 52(8): 1268-1275
• ORIGINAL ARTICLES •
Network pharmacology-based study on intervention mechanism of Huanglian Jiedu decoction in the treatment of Alzheimer's disease
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Li-min SUN1, 2, 3, Li-fang LIU1, *, Hua-xu ZHU2, 3, *, Bao-jie ZHU2, 3, Qi-chun ZHANG2, 3
Affiliations
  • 1. The State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
  • 2. Jiangsu Collaboration Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 3. Jiangsu Botanical Medicine Refinement Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing 210029, China
Published: 2017-08-12 doi: 10.16438/j.0513-4870.2017-0144
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This study was designed to explore the "multi-components, multi-targets and multi-pathways" intervention mechanism of Huanglian Jiedu decoction (HLJDD) in the treatment of Alzheimer's disease (AD) by pharmacological network technology, which may establish a foundation for drug development and innovative research. Seventeen active constituents of HLJDD with anti-AD activities were submitted to PharmMapper and Molecule Annotation System (MAS 3.0) bioinformatics softwares to predict the target proteins and carry out related KEGG pathways annotation respectively. The network of "active compound-target-pathway" was constructed and analyzed using the Cytoscape 3.4.0 software. The results suggest that 47 pathways are affected by the 17 active components through 59 target proteins, in which 4 target proteins are related to AD and 2 pathways related to neuroinflammation, respectively. The effect of HLJDD on AD may be dependent on clearing/reducing β-amyloid protein, inhibiting Tau hyperphosphorylation, anti-inflammation and immunoregulation.

network pharmacology  /  Huanglian Jiedu decoction  /  Alzheimer's disease  /  mechanism  /  molecular docking
Li-min SUN, Li-fang LIU, Hua-xu ZHU, Bao-jie ZHU, Qi-chun ZHANG. Network pharmacology-based study on intervention mechanism of Huanglian Jiedu decoction in the treatment of Alzheimer's disease[J]. Acta Pharmaceutica Sinica, 2017 , 52 (8) : 1268 -1275 . DOI: 10.16438/j.0513-4870.2017-0144
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Article Info
doi: 10.16438/j.0513-4870.2017-0144
  • Receive Date：2017-02-17
  • Online Date：2026-01-14
  • Published：2017-08-12
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History
  • Received：2017-02-17
  • Revised：2017-03-21
Funding
Affiliations
    1. The State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
    2. Jiangsu Collaboration Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
    3. Jiangsu Botanical Medicine Refinement Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing 210029, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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