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Synthesis of functional phospholipids and preparation of shear-stress sensitive liposomes
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Qin KE1, 2, Ping-yuan WANG2, Yun-qiu MIAO2, Jin-ying LIANG2, Shu-fang HE2, Xin-xin ZHANG2, *, Yong GAN2, *
Acta Pharmaceutica Sinica | 2017, 52(7) : 1178 - 1185
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Acta Pharmaceutica Sinica | 2017, 52(7): 1178-1185
• ORIGINAL ARTICLES •
Synthesis of functional phospholipids and preparation of shear-stress sensitive liposomes
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Qin KE1, 2, Ping-yuan WANG2, Yun-qiu MIAO2, Jin-ying LIANG2, Shu-fang HE2, Xin-xin ZHANG2, *, Yong GAN2, *
Affiliations
  • 1. School of Pharmaceutical Sciences, Nanchang University, Nanchang 330006, China
  • 2. Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai 201203, China
Published: 2017-07-12 doi: 10.16438/j.0513-4870.2017-0136
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This study aims to synthesize new phospholipids, 1, 3-dipalmaminophospholipid(Pad-PC-Pad), and prepare shear-stress sensitive liposomes(SSSL). 1H NMR and MS indicated that Pad-PC-Pad were fully synthesized successfully. SSSL were prepared by filming-rehydration method with Pad-PC-Pad, which loaded calcein with aggregation-caused quenching(ACQ)characteristics to evaluate shear-stress sensitivity of liposomes and release behavior of liposomes in vitro. The results showed that the particle size of liposomes was 106.91 ± 1.24 nm and liposomes had lenticular morphology under transmission electron microscope. The release of calcein was increased with ultrasonic power, which suggests that the liposomes is shear-stress sensitive. Moreover, the liposomes exhibited a releasing effect for obstructed region under high shear-stress in a model system. Therefore, we synthesized quick functional phospholipid Pad-PC-Pad and the liposomes made from Pad-PC-Pad was shear-stress sensitive, which may be used for treatment of thrombosis.

liposome  /  thrombosis  /  sensitivity  /  fluorescent dye  /  specificity
Qin KE, Ping-yuan WANG, Yun-qiu MIAO, Jin-ying LIANG, Shu-fang HE, Xin-xin ZHANG, Yong GAN. Synthesis of functional phospholipids and preparation of shear-stress sensitive liposomes[J]. Acta Pharmaceutica Sinica, 2017 , 52 (7) : 1178 -1185 . DOI: 10.16438/j.0513-4870.2017-0136
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Article Info
doi: 10.16438/j.0513-4870.2017-0136
  • Receive Date：2017-02-16
  • Online Date：2026-01-14
  • Published：2017-07-12
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  • Received：2017-02-16
  • Revised：2017-03-17
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    1. School of Pharmaceutical Sciences, Nanchang University, Nanchang 330006, China
    2. Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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