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Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety
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Yi LIU1, 2, 3, Wei LU1, 2, 3, Qing-chuan LIU4, Zheng-ming HUANG4, Guang-yi LIANG2, 3, 5, *, Bi-xue XU2, 3, *
Acta Pharmaceutica Sinica | 2017, 52(7) : 1140 - 1145
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Acta Pharmaceutica Sinica | 2017, 52(7): 1140-1145
• ORIGINAL ARTICLES •
Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety
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Yi LIU1, 2, 3, Wei LU1, 2, 3, Qing-chuan LIU4, Zheng-ming HUANG4, Guang-yi LIANG2, 3, 5, *, Bi-xue XU2, 3, *
Affiliations
  • 1. College of Pharmacy, Guizhou University, Guiyang 550002, China
  • 2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medcial University, Guiyang 550014, China
  • 3. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China
  • 4. 302 Hospital of PLA, Beijing 100039, China
  • 5. Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China
Published: 2017-07-12 doi: 10.16438/j.0513-4870.2017-0059
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In this study, eleven containing gallic acid moiety derivatives of Matijin-Su(MTS)were synthesized and evaluated for their anti-HBV activities in HepG2 2.2.15 cells in an effort to find novel effective anti-hepatitis B virus(HBV)agents. Compounds 5c, 6c and 6d exhibited significant anti-HBV activity with IC50 values of 6.12, 8.44 and 9.86 μmol·L-1, respectively. Incorporation of gallic acid moiety into MTS derivatives can lead to profound changes in their anti-HBV activity, and could be worth of further research.

hepatitis B virus  /  derivative of Matijin-Su  /  synthesis  /  biological activity
Yi LIU, Wei LU, Qing-chuan LIU, Zheng-ming HUANG, Guang-yi LIANG, Bi-xue XU. Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety[J]. Acta Pharmaceutica Sinica, 2017 , 52 (7) : 1140 -1145 . DOI: 10.16438/j.0513-4870.2017-0059
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Article Info
doi: 10.16438/j.0513-4870.2017-0059
  • Receive Date：2017-01-16
  • Online Date：2026-01-14
  • Published：2017-07-12
Article Data
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History
  • Received：2017-01-16
  • Revised：2017-02-18
Funding
Affiliations
    1. College of Pharmacy, Guizhou University, Guiyang 550002, China
    2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medcial University, Guiyang 550014, China
    3. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China
    4. 302 Hospital of PLA, Beijing 100039, China
    5. Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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