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Co-chaperones: regulated action in conformational functions of HSP90 and their actions in cancer
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Ni-na XUE, Jing JIN, Xiao-guang CHEN*
Acta Pharmaceutica Sinica | 2017, 52(7) : 1085 - 1090
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Acta Pharmaceutica Sinica | 2017, 52(7): 1085-1090
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Co-chaperones: regulated action in conformational functions of HSP90 and their actions in cancer
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Ni-na XUE, Jing JIN, Xiao-guang CHEN*
Affiliations
  • State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2017-07-12 doi: 10.16438/j.0513-4870.2017-0020
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Heat shock protein 90(HSP90), as an essential molecular chaperone, regulates the folding, assembly and maturation of a wide range of oncogenic client proteins. The process of adenosine triphosphate(ATP)binding and adenosine diphosphate(ADP)/ATP exchange act as a conformational switch to regulate the chaperone function of HSP90. Furthermore, this process is controlled by a range of accessory proteins(as referred to co-chaperones), such as Hop, CDC37, p23, AHA1, PP5, etc. This article describes the structure and function of several co-chaperones, and their roles in tumor progress.

cancer  /  heat shock protein 90  /  co-chaperone  /  client protein  /  adenosine triphosphate
Ni-na XUE, Jing JIN, Xiao-guang CHEN. Co-chaperones: regulated action in conformational functions of HSP90 and their actions in cancer[J]. Acta Pharmaceutica Sinica, 2017 , 52 (7) : 1085 -1090 . DOI: 10.16438/j.0513-4870.2017-0020
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Article Info
doi: 10.16438/j.0513-4870.2017-0020
  • Receive Date：2017-01-05
  • Online Date：2026-01-14
  • Published：2017-07-12
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  • Received：2017-01-05
  • Revised：2017-02-14
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    State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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