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Natural modulators of transient receptor potential channels
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Nan-kai CAO1, Hai-ning LÜ1, Ning-ning WEI2, Jun LI1, Peng-fei TU1, Ke-wei WANG2, *, Yong JIANG1, *
Acta Pharmaceutica Sinica | 2017, 52(5) : 673 - 684
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Acta Pharmaceutica Sinica | 2017, 52(5): 673-684
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Natural modulators of transient receptor potential channels
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Nan-kai CAO1, Hai-ning LÜ1, Ning-ning WEI2, Jun LI1, Peng-fei TU1, Ke-wei WANG2, *, Yong JIANG1, *
Affiliations
  • 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
  • 2. School of Pharmacy, Qingdao University, Qingdao 266021, China
Published: 2017-05-12 doi: 10.16438/j.0513-4870.2016-1187
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Transient receptor potential (TRP) channels are non-selective and cation-permeable channels in the cell membrane, widely distributed in tissues and organs of human body. As biosensors, TRP channels can regulate the functions of vision, hearing, taste, pain, and touch, etc. So far, more than 100 different kinds of natural modulators targeting TRP channels have been identified from 70 species of plants or animals. In this review article, we attempt to summarize the effect of known natural active compounds on TRP channels with focuses on their sources, structures, action features and mechanisms. Hopefully this review can provide some useful information that can facilitate discovery of more specific natural modulators, and development of innovative therapeutic drugs targeting TRP channels.

transient receptor potential channel  /  natural modulator  /  TRPV  /  TRPA  /  TRPM  /  TRPC  /  capsaicin
Nan-kai CAO, Hai-ning LÜ, Ning-ning WEI, Jun LI, Peng-fei TU, Ke-wei WANG, Yong JIANG. Natural modulators of transient receptor potential channels[J]. Acta Pharmaceutica Sinica, 2017 , 52 (5) : 673 -684 . DOI: 10.16438/j.0513-4870.2016-1187
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Article Info
doi: 10.16438/j.0513-4870.2016-1187
  • Receive Date：2016-12-14
  • Online Date：2026-01-14
  • Published：2017-05-12
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History
  • Received：2016-12-14
  • Revised：2017-02-07
Funding
Affiliations
    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    2. School of Pharmacy, Qingdao University, Qingdao 266021, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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