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Network pharmacology study of the effective constituents in the Compound Yizhihao against influenza disease
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Lü-jie XU1, Wen JIANG2, Xiao-cong PANG1, De KANG1, Wan-di XIONG1, Rui LIU1, Jian-guo XING3, Ai-lin LIU1, *, Guan-hua DU1
Acta Pharmaceutica Sinica | 2017, 52(5) : 745 - 752
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Acta Pharmaceutica Sinica | 2017, 52(5): 745-752
• ORIGINAL ARTICLES Pharmacology •
Network pharmacology study of the effective constituents in the Compound Yizhihao against influenza disease
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Lü-jie XU1, Wen JIANG2, Xiao-cong PANG1, De KANG1, Wan-di XIONG1, Rui LIU1, Jian-guo XING3, Ai-lin LIU1, *, Guan-hua DU1
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. The Sixth Affiliated Hospital, Xinjiang Medical University, Urumchi 830002, China
  • 3. The Xinjiang Institute of Materia Medica, Urumchi 830002, China
Published: 2017-05-12 doi: 10.16438/j.0513-4870.2016-1172
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Compound Yizhihao, consists of Radix isatidis, Folium isatidis, Artemisia rupestris, has a significant therapeutic effect on the treatment of influenza and fever. However, the mechanism of its action is still unclear. In this investigation, we collected the key target molecule of influenza disease and the chemical constituents of Compound Yizhihao, and developed Naïve Bayesian classification models based on the input molecular fingerprints and molecule descriptors. The built models were further applied to construct classifiers for predicting the effective constituents. We used the professional network-building software to build the constituent-target network and target-pathway network, which revealed the network pharmacology of the effective constituents in Compound Yizhihao. It will contribute to the further research of mechanism of Compound Yizhihao.

Compound Yizhihao  /  influenza  /  drug target  /  Naïve Bayesian classification model  /  molecular fingerprint  /  molecule descriptor  /  network pharmacology
Lü-jie XU, Wen JIANG, Xiao-cong PANG, De KANG, Wan-di XIONG, Rui LIU, Jian-guo XING, Ai-lin LIU, Guan-hua DU. Network pharmacology study of the effective constituents in the Compound Yizhihao against influenza disease[J]. Acta Pharmaceutica Sinica, 2017 , 52 (5) : 745 -752 . DOI: 10.16438/j.0513-4870.2016-1172
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Article Info
doi: 10.16438/j.0513-4870.2016-1172
  • Receive Date：2016-12-05
  • Online Date：2026-01-14
  • Published：2017-05-12
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History
  • Received：2016-12-05
  • Revised：2017-01-16
Funding
Affiliations
    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. The Sixth Affiliated Hospital, Xinjiang Medical University, Urumchi 830002, China
    3. The Xinjiang Institute of Materia Medica, Urumchi 830002, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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