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Molecular mechanism of Xuebijing injection in treatment of sepsis according to "drug-target-pathway" network
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Yan-yan FENG1, 2, Yuan-yuan XIE2, *, Yan-ping WANG2, Qi LIAN2, Yi-ming WANG2, Guo-an LUO1, 2, Shu-mei WANG1, *
Acta Pharmaceutica Sinica | 2017, 52(4) : 556 - 562
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Acta Pharmaceutica Sinica | 2017, 52(4): 556-562
• ORIGINAL ARTICLES Pharmacology •
Molecular mechanism of Xuebijing injection in treatment of sepsis according to "drug-target-pathway" network
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Yan-yan FENG1, 2, Yuan-yuan XIE2, *, Yan-ping WANG2, Qi LIAN2, Yi-ming WANG2, Guo-an LUO1, 2, Shu-mei WANG1, *
Affiliations
  • 1. School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • 2. Department of Chemistry, Tsinghua University, Beijing 100084, China
Published: 2017-04-12 doi: 10.16438/j.0513-4870.2016-1048
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This study was aimed to construct a "drug-target-pathway" network of Xuebijing injection for sepsis treatment in an effort to explore the "multi-components, multi-targets, multi-pathways" mechanism based on "system-system" research mode. Active ingredients of Xuebijing injection were used to predict the potential targets according to reversed pharmacophore matching method. The pathway information was acquired from DAVID and KEGG database. The Cytoscape software was used to construct the "ingredient-target-pathway" network of Xuebijing injection for sepsis treatment. The results showed that 21 major active ingredients of Xuebijing injection regulated 550 targets (HRAS, GSK3B, BTK, AK, et al) and affected 10 inflammation and immune-related pathways, such as B cell receptor signaling pathway, VEGF signaling pathway, natural killer cell mediated cytotoxicity, Toll-like receptor signaling pathway. The sepsis therapeutic effect of Xuebijing injection reflected the action features of traditional Chinese medicine as multi-ingredients, multi-targets, multi-pathways. This research clarifies the material basis of Xuebijing injection for anti-inflammation and immunoregulation, providing a scientific basis for elucidation the mechanism of Xuebijing injection in the treatment of sepsis.

network pharmacology  /  Xuebijing injection  /  sepsis  /  anti-inflammation  /  immune-regulation  /  material basis
Yan-yan FENG, Yuan-yuan XIE, Yan-ping WANG, Qi LIAN, Yi-ming WANG, Guo-an LUO, Shu-mei WANG. Molecular mechanism of Xuebijing injection in treatment of sepsis according to "drug-target-pathway" network[J]. Acta Pharmaceutica Sinica, 2017 , 52 (4) : 556 -562 . DOI: 10.16438/j.0513-4870.2016-1048
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doi: 10.16438/j.0513-4870.2016-1048
  • Receive Date：2016-10-28
  • Online Date：2026-01-14
  • Published：2017-04-12
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  • Received：2016-10-28
  • Revised：2017-01-05
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    1. School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
    2. Department of Chemistry, Tsinghua University, Beijing 100084, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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