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On-line detection of concentration process of Ganmaoling granules by near infrared spectroscopy combined with automatic control system
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Xue-song LIU1, Jia-shan CHEN1, Guo-quan CHEN1, Ping SHAO2, Yong-jiang WU1, *
Acta Pharmaceutica Sinica | 2017, 52(3) : 462 - 467
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Acta Pharmaceutica Sinica | 2017, 52(3): 462-467
On-line detection of concentration process of Ganmaoling granules by near infrared spectroscopy combined with automatic control system
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Xue-song LIU1, Jia-shan CHEN1, Guo-quan CHEN1, Ping SHAO2, Yong-jiang WU1, *
Affiliations
  • 1. Institute of Modern Chinese Medicine, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China
  • 2. NERC for the Pharmaceutical of Traditional Chinese Medicines, Benxi 117000, China
Published: 2017-03-12 doi: 10.16438/j.0513-4870.2016-1030
Outline
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Our research was designed for on-line detection of multi-index in the concentration process of Ganmaoling granules by integration of near infrared spectroscopy and automatic control system. First, on-line detection system was set up in the concentration tank for Ganmaoling granules production. Spectra were scanned and values of chlorogenic acid, linarin, solid content and relative density were measured. Models of partial least squares regression were built and imported into near infrared workstation. By connecting the control system, real-time multi-index values were determined automatically in the concentration process. Results showed that correlation coefficients of chlorogenic acid, linarin, solid content and relative density models were 0.963, 0.989, 0.993 and 0.918, respectively. Relative standard errors of prediction were 3.71%, 4.28%, 4.17% and 0.24%, respectively, indicating a good performance and high accuracy of the models. Real-time data collection during the whole process was measured by the near infrared detecting system in the control system. In conclusion, the near infrared detection system is able to perform real-time automatic determination of multi-index in the concentration process of Ganmaoling granules with significant advantages.

near infrared spectroscopy  /  automatic control system  /  Ganmaoling granule  /  process analytical technology
Xue-song LIU, Jia-shan CHEN, Guo-quan CHEN, Ping SHAO, Yong-jiang WU. On-line detection of concentration process of Ganmaoling granules by near infrared spectroscopy combined with automatic control system[J]. Acta Pharmaceutica Sinica, 2017 , 52 (3) : 462 -467 . DOI: 10.16438/j.0513-4870.2016-1030
Year 2017 volume 52 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2016-1030
  • Receive Date:2016-10-21
  • Online Date:2026-01-14
  • Published:2017-03-12
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  • Received:2016-10-21
  • Revised:2016-12-27
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    1. Institute of Modern Chinese Medicine, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China
    2. NERC for the Pharmaceutical of Traditional Chinese Medicines, Benxi 117000, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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