Home Journals Articles Updates About
CN
image
收藏切换
Advances and challenges in preclinical evaluation of therapeutic drugs for treating ischemic stroke
收藏切换
PDF
Ying PENG1, Fei MA1, Ting-ting XU1, Shan WANG1, Long-jian HUANG1, Xiao-ying WANG2, *, Yong-jun WANG3, *, Xiao-liang WANG1, *
Acta Pharmaceutica Sinica | 2017, 52(3) : 339 - 346
Less
收藏切换
Acta Pharmaceutica Sinica | 2017, 52(3): 339-346
• PROFESSIONALS FORUM •
Advances and challenges in preclinical evaluation of therapeutic drugs for treating ischemic stroke
Full
Ying PENG1, Fei MA1, Ting-ting XU1, Shan WANG1, Long-jian HUANG1, Xiao-ying WANG2, *, Yong-jun WANG3, *, Xiao-liang WANG1, *
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
  • 3. Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China
Published: 2017-03-12 doi: 10.16438/j.0513-4870.2016-1018
Outline
收藏切换

Translating of scientific advances into clinical practice is a major challenge in the stroke research field in the past decades. There were many reasons involved:animal models might not accurately capture all aspects of clinical stroke in humans, the blind and randomized design principle was not closely followed, the inclusion and exclusion criteria was not previously established, sample size was inadequate, endpoint was not scientific nor blindly assessed, inadequate reporting of data and statistical flaws. To bridge the gap between experimental and clinical research, international consortia have attempted to establish standardized guidelines for study design and data report, which include optimizing animal models as well as experimental design, using innovative approaches to assess endpoint, making raw data and negative results available, establishing prior registration mechanism, conducting multicenter preclinical randomized controlled trials (pRCTs), systematic reviews and meta-analysis of preclinical studies, evolving the original focus on neuroprotection into a broader consideration of the role of neurovascular unit and ischemic cascade.

ischemic stroke  /  therapeutic drug  /  preclinical research  /  clinical translation
Ying PENG, Fei MA, Ting-ting XU, Shan WANG, Long-jian HUANG, Xiao-ying WANG, Yong-jun WANG, Xiao-liang WANG. Advances and challenges in preclinical evaluation of therapeutic drugs for treating ischemic stroke[J]. Acta Pharmaceutica Sinica, 2017 , 52 (3) : 339 -346 . DOI: 10.16438/j.0513-4870.2016-1018
Appendix
Less
Year 2017 volume 52 Issue 3
PDF
175
77
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2016-1018
  • Receive Date：2016-10-19
  • Online Date：2026-01-14
  • Published：2017-03-12
Article Data
Affiliations
History
  • Received：2016-10-19
  • Revised：2016-11-25
Funding
Affiliations
    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    3. Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2016-1018
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House