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Recent progress of reactive oxygen species-responsive drug delivery systems
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Guang-zhao LU, Cheng HOU, Yan-qiang ZHONG, Ying LU, Hao ZOU*
Acta Pharmaceutica Sinica | 2017, 52(2) : 206 - 213
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Acta Pharmaceutica Sinica | 2017, 52(2): 206-213
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Recent progress of reactive oxygen species-responsive drug delivery systems
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Guang-zhao LU, Cheng HOU, Yan-qiang ZHONG, Ying LU, Hao ZOU*
Affiliations
  • School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Published: 2017-02-12 doi: 10.16438/j.0513-4870.2016-0923
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Excessive reactive oxygen species (ROS) is associated with an array of pathological conditions, including cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases. However, ROS-responsive materials have drawn attention in the development of drug delivery systems. There are many types of ROS-responsive materials explored in drug delivery applications, including sulfur-based responsive polymers, selenium-based responsive polymers, tellurium-based responsive polymers, oxalate ester-containing polymers, phenylboronic ester-containing polymers and unsaturated lipids. When integrated with ROS-responsive drug delivery systems, a photosensitizer is used as a light-sensitive element to generate ROS, mainly singlet oxygen (1O2), which in turn activates the ROS-triggered drug delivery.

reactive oxygen species  /  drug delivery system  /  photosensitizer  /  singlet oxygen
Guang-zhao LU, Cheng HOU, Yan-qiang ZHONG, Ying LU, Hao ZOU. Recent progress of reactive oxygen species-responsive drug delivery systems[J]. Acta Pharmaceutica Sinica, 2017 , 52 (2) : 206 -213 . DOI: 10.16438/j.0513-4870.2016-0923
Year 2017 volume 52 Issue 2
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doi: 10.16438/j.0513-4870.2016-0923
  • Receive Date:2016-09-20
  • Online Date:2026-01-14
  • Published:2017-02-12
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  • Received:2016-09-20
  • Revised:2016-11-09
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    School of Pharmacy, Second Military Medical University, Shanghai 200433, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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