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Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency
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Shu-fen HE1, Wen-zheng JU1, *, Hao-bin HU2, Li-jing ZHU1, Qian ZHANG1, Guo-liang DAI1
Acta Pharmaceutica Sinica | 2017, 52(2) : 258 - 263
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Acta Pharmaceutica Sinica | 2017, 52(2): 258-263
• ORIGINAL ARTICLES •
Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency
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Shu-fen HE1, Wen-zheng JU1, *, Hao-bin HU2, Li-jing ZHU1, Qian ZHANG1, Guo-liang DAI1
Affiliations
  • 1. Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
  • 2. Jiangsu Institute for Food and Drug Control, Nanjing 210008, China
Published: 2017-02-12 doi: 10.16438/j.0513-4870.2016-0831
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This study was designed to explore the impact of depression on kidney-yang deficiency in rats. Rats were repeatedly injected with hydrocortisone for 21 days to establish the depression model with kidneyyang deficiency. Tolbutamide, chlorzoxazone, theophylline, midazolam, omeprazole and dextromethorphan were used as substrates of CYP2C6, CYP2E1, CYP1A2, CYP3A2, CYP2D1, and CYP2D2 to test the depression impact on drug metabolism. Plasma concentrations of six CYP450 were determined by LC-MS/MS and used as pharmacokinetic parameters. Consequently, metabolism of theophylline, chlorzoxazone and tolbutamide were accelerated significantly in the model relative to the control (P < 0.01), but dextromethorphan, omeprazole and midazolam did not exhibit a significant difference. The present study suggests that depression with kidneyyang deficiency had a strong induction of CYP2E1 and moderate induction of CYP1A2, CYP2C6 in the rat model.

depression  /  kidney-yang deficiency  /  cocktail probe drug  /  LC-MS/MS  /  cytochrome P450
Shu-fen HE, Wen-zheng JU, Hao-bin HU, Li-jing ZHU, Qian ZHANG, Guo-liang DAI. Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency[J]. Acta Pharmaceutica Sinica, 2017 , 52 (2) : 258 -263 . DOI: 10.16438/j.0513-4870.2016-0831
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Article Info
doi: 10.16438/j.0513-4870.2016-0831
  • Receive Date：2016-08-23
  • Online Date：2026-01-14
  • Published：2017-02-12
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  • Received：2016-08-23
  • Revised：2016-10-26
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    1. Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
    2. Jiangsu Institute for Food and Drug Control, Nanjing 210008, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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