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Effects of metoprolol or/and pravastatin on the pharmacokinetics of metformin in rats
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Yan-rong MA1, Yan-fang WU1, 2, Ying-qin DUAN1, 2, Guo-qiang ZHANG1, Xin-an WU1, *
Acta Pharmaceutica Sinica | 2017, 52(2) : 253 - 257
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Acta Pharmaceutica Sinica | 2017, 52(2): 253-257
• ORIGINAL ARTICLES •
Effects of metoprolol or/and pravastatin on the pharmacokinetics of metformin in rats
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Yan-rong MA1, Yan-fang WU1, 2, Ying-qin DUAN1, 2, Guo-qiang ZHANG1, Xin-an WU1, *
Affiliations
  • 1. The First Hospital, Lanzhou University, Lanzhou 730000, China
  • 2. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
Published: 2017-02-12 doi: 10.16438/j.0513-4870.2016-0755
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This study investigates the effects of metoprolol (METO) or/and pravastatin (PRAV) on the pharmacokinetics of metformin (METF) in rats. Twenty-eight male SD rats were divided into METF group, METF+METO group, METF+PRAV group and METF+METO+PRAV group. Blood samples were collected at 10, 20, 40, 60, 90, 120, 180, 240, 360, 480 and 600 min after oral administration of metformin, and concentration of metformin in plasma was determined by HPLC. Compared to the METF group, Cmax of metformin was significantly decreased (P < 0.01) and MRT0-t, t1/2 and V were significantly increased in the METF+METO group; t1/2 was significantly decreased in the METF+PRAV group; Cmax was significantly decreased and MRT0-t was significantly increased in the METF+METO+PRAV group. Compared to the METF+METO group, MRT0-t of metformin was significantly decreased in the METF+METO+PRAV group. Compared to the METF+PRAV group, Cmax of metformin was significantly decreased (P < 0.01), and MRT0-t, t1/2 and V were significantly increased in the METF+METO+PRAV group. There exist multiple drug interactions of metformin, metoprolol and pravastatin in rats.

metformin  /  metoprolol  /  pravastatin  /  multiple drug interaction  /  pharmacokinetics
Yan-rong MA, Yan-fang WU, Ying-qin DUAN, Guo-qiang ZHANG, Xin-an WU. Effects of metoprolol or/and pravastatin on the pharmacokinetics of metformin in rats[J]. Acta Pharmaceutica Sinica, 2017 , 52 (2) : 253 -257 . DOI: 10.16438/j.0513-4870.2016-0755
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doi: 10.16438/j.0513-4870.2016-0755
  • Receive Date：2016-08-12
  • Online Date：2026-01-14
  • Published：2017-02-12
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  • Received：2016-08-12
  • Revised：2016-10-12
Affiliations
    1. The First Hospital, Lanzhou University, Lanzhou 730000, China
    2. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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