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Personalized dosing from perspective of pharmacogenomics of drug metabolizing enzymes and transporters
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Quan ZHOU1, *, Lu-shan YU2, Su ZENG2
Acta Pharmaceutica Sinica | 2017, 52(1) : 1 - 7
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Acta Pharmaceutica Sinica | 2017, 52(1): 1-7
• SPECIAL REPORTS •
Personalized dosing from perspective of pharmacogenomics of drug metabolizing enzymes and transporters
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Quan ZHOU1, *, Lu-shan YU2, Su ZENG2
Affiliations
  • 1. The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
  • 2. Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Published: 2017-01-12 doi: 10.16438/j.0513-4870.2016-0562
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Pharmacogenomics is defined as research into the relationship between inherited genetic variations in drug metabolizing enzymes, transporters and targets and individual variations in person's response to drugs (fate of drug in human body, safety and efficacy). Personalized dosing is pharmacogenomics-based therapeutic regimen tailored to other individual characteristics. This article summarizes the progress in clinical application of personalized dosing from the perspective of pharmacogenomics of drug metabolizing enzymes and transporters, and proposes to draw attention to key scientific issues (e.g., the effect of multi-genes and non-genetic factors on drug effects, the integration of therapeutic drug monitoring and pharmacogenomics); meanwhile, bottle necks in the clinical application and corresponding strategies are proposed.

drug metabolism  /  transporter  /  personalized dosing  /  pharmacogenomics  /  combinatorial pharmacogenomics  /  phenoconversio
Quan ZHOU, Lu-shan YU, Su ZENG. Personalized dosing from perspective of pharmacogenomics of drug metabolizing enzymes and transporters[J]. Acta Pharmaceutica Sinica, 2017 , 52 (1) : 1 -7 . DOI: 10.16438/j.0513-4870.2016-0562
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Article Info
doi: 10.16438/j.0513-4870.2016-0562
  • Receive Date：2016-06-08
  • Online Date：2026-01-14
  • Published：2017-01-12
Article Data
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History
  • Received：2016-06-08
  • Revised：2016-08-21
Funding
Affiliations
    1. The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    2. Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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