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Study of cancer cell apoptosis induced by Schizonepeta tenuifolia with microfluidic chip technology
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Jia-xin FAN1, Shuai WANG1, 2, 3, Xian-sheng MENG1, 2, 3, *, Yong-rui BAO1, 2, 3, Tian-jiao LI1, 2, 3
Acta Pharmaceutica Sinica | 2017, 52(1) : 126 - 131
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Acta Pharmaceutica Sinica | 2017, 52(1): 126-131
ORIGINAL ARTICLES
Study of cancer cell apoptosis induced by Schizonepeta tenuifolia with microfluidic chip technology
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Jia-xin FAN1, Shuai WANG1, 2, 3, Xian-sheng MENG1, 2, 3, *, Yong-rui BAO1, 2, 3, Tian-jiao LI1, 2, 3
Affiliations
  • 1. College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
  • 2. Liaoning Province Multi-Component Chinese Medicine Engineering Technology Research Center, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
  • 3. Liaoning Province Modern Traditional Chinese Medicine Research and Engineering Laboratory, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
Published: 2017-01-12 doi: 10.16438/j.0513-4870.2016-0466
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This study was designed to elucidate the chemical composition and anti-cancer effects of Schizonepeta tenuifolia's ethanol extracts. Microfluidic technology was used in the study of Schizonepeta tenuifolia from 9 different geographic regions. The ethanol extracts were examined with HPLC to establish their Fingerprints in order to analyze the relationship between the spectrum and efficacy index through Grey Correlation software, and a rapid HPLC-Q-TOF/MS method was established. The result shows that chromatographic peaks of the 19, 6, 11, 16, 18th are the representative diosmetin, luteoloside, hesperidin, luteolin, and apigenin. The 10, 12, 20th peaks may be naringenin-7-O-glucuronide or quercitrin, rosmarinate or acetylcorynoline, and 5,7-dihydroxy-6,4-dimethoxy flavone. The major chemical composition of Schizonepeta tenuifolia was found to have the anti-lung-tumor effects. A new method was established for the quality control of traditional Chinese medicine.

Schizonepeta tenuifolia  /  microfluidic chip  /  A549 cell  /  spectrum effect relationship  /  grey correlation degree
Jia-xin FAN, Shuai WANG, Xian-sheng MENG, Yong-rui BAO, Tian-jiao LI. Study of cancer cell apoptosis induced by Schizonepeta tenuifolia with microfluidic chip technology[J]. Acta Pharmaceutica Sinica, 2017 , 52 (1) : 126 -131 . DOI: 10.16438/j.0513-4870.2016-0466
Year 2017 volume 52 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2016-0466
  • Receive Date:2016-08-24
  • Online Date:2026-01-14
  • Published:2017-01-12
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  • Received:2016-08-24
  • Revised:2016-09-20
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Affiliations
    1. College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
    2. Liaoning Province Multi-Component Chinese Medicine Engineering Technology Research Center, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
    3. Liaoning Province Modern Traditional Chinese Medicine Research and Engineering Laboratory, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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