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Optimization of extraction process of Impatientis Balsaminae Caulis based on network pharmacology and mixture weighting methods*
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Xue-feng MU1, Ming WU2, Chao-mei ZHOU2, Jing SHI2, Yuan-yuan YOU2, **
Chinese Journal of Pharmaceutical Analysis | 2024, 44(11) : 1932 - 1943
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Chinese Journal of Pharmaceutical Analysis | 2024, 44(11): 1932-1943
• Process Evaluation • Standard Deliberation •
Optimization of extraction process of Impatientis Balsaminae Caulis based on network pharmacology and mixture weighting methods*
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Xue-feng MU1, Ming WU2, Chao-mei ZHOU2, Jing SHI2, Yuan-yuan YOU2, **
Affiliations
  • 1.Department of Acupuncture and Rehabilitation，the First Affiliated Hospital of Traditional Chinese Medicine of Chengdu Medical College，Chengdu 610500，China
  • 2.Department of Pharmacy，Chengdu Medical College，Chengdu 610500，China
Published: 2024-12-01 doi: 10.16155/j.0254-1793.2023-0717
Outline
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Objective:

To optimize the extraction process of Impatientis Balsaminae Caulis in the treatment of degenerative osteoarthritis based on network pharmacology，mixture weighting and response surface method.

Methods:

Network pharmacology and LC-MS techniques were used to determine the active ingredients of Impatientis Balsaminae Caulis in the treatment of osteoarthritis，and they were taken as evaluation indexes. The extraction process of Impatientis Balsaminae Caulis was optimized by analytic hierarchy process（AHP）-criteria importance through intercriteria correlation(CRITIC) mixed weighting method and Box-Behnken response surface design.

Results:

Scopoletin，quercetin and kaempferol were the active ingredients in the treatment of osteoarthritis. The optimal extraction process was to add 5 times of 82% ethanol and reflux twice，35 min each time.

Conclusion:

The treatment of osteoarthritis can be achieved by regulating target genes and related signaling pathways through various active components. The weight coefficient determined by AHP-CRITIC hybrid weighting method is objective and reasonable，and the optimized extraction process is stable and feasible.

Impatientis Balsaminae Caulis  /  osteoarthritis  /  network pharmacology  /  molecular docking  /  analytic hierarchy process（AHP）  /  criteria importance through intercrieria correlation（CRITIC）  /  response surface method
Xue-feng MU, Ming WU, Chao-mei ZHOU, Jing SHI, Yuan-yuan YOU. Optimization of extraction process of Impatientis Balsaminae Caulis based on network pharmacology and mixture weighting methods*[J]. Chinese Journal of Pharmaceutical Analysis, 2024 , 44 (11) : 1932 -1943 . DOI: 10.16155/j.0254-1793.2023-0717
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Year 2024 volume 44 Issue 11
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Article Info
doi: 10.16155/j.0254-1793.2023-0717
  • Receive Date：2023-11-09
  • Online Date：2026-03-18
  • Published：2024-12-01
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History
  • Received：2023-11-09
Funding
Affiliations
    1.Department of Acupuncture and Rehabilitation，the First Affiliated Hospital of Traditional Chinese Medicine of Chengdu Medical College，Chengdu 610500，China
    2.Department of Pharmacy，Chengdu Medical College，Chengdu 610500，China
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https://castjournals.cast.org.cn/joweb/ywfxzz/EN/10.16155/j.0254-1793.2023-0717
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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