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Metabolomics，as a branch of systems biology，utilizes high-throughput omics technology to investigate metabolite changes within organisms，which enable us to explore the relationship between such alterations and disease etiology or evolution，thereby providing novel research insights for identifying relevant biomarkers and screening of diseases. In recent years，metabolomics has been widely used in the field of cancer research. At the same time，the changes of metabolic pathways can be deeply discussed by using the network shared database. Given that colorectal cancer ranks as the second most prevalent malignant tumor in China，it is crucial to search for clinically valuable tumor markers. This article will highlight the progress of recent five-year metabolomics studies in different matrices to identify potential biomarkers associated with colorectal cancer（CRC），so as to provide references for early screening of CRC.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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