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Simultaneou determination of 22 components in Bimin capsules by UPLC-MS/MS*
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Lei CAO1, 2, Jian-yun BI1, Yu-qing WANG2, **, Xin-jun ZHANG2, Ming SU2, 1, Bo-yang WANG2, Xin-rui LI2, Xin-ru SUN2, Kang-ning XIAO2, Yu-jie HOU1, 2, Sheng-mei LIU3, Qian ZHOU2, Shan-xin LIU2, **
Chinese Journal of Pharmaceutical Analysis | 2025, 45(3) : 400 - 408
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Chinese Journal of Pharmaceutical Analysis | 2025, 45(3): 400-408
• Ingredient Analysis •
Simultaneou determination of 22 components in Bimin capsules by UPLC-MS/MS*
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Lei CAO1, 2, Jian-yun BI1, Yu-qing WANG2, **, Xin-jun ZHANG2, Ming SU2, 1, Bo-yang WANG2, Xin-rui LI2, Xin-ru SUN2, Kang-ning XIAO2, Yu-jie HOU1, 2, Sheng-mei LIU3, Qian ZHOU2, Shan-xin LIU2, **
Affiliations
  • 1. Shandong University of Chinese Medicine, Jinan 250355, China
  • 2. Shandong Academy of Traditional Chinese Medicine,Jinan 250014, China
  • 3. Shandong Kangzhonghong Pharmaceutical Technology Development Co., Ltd, Jinan, 250061, China
Published: 2025-03-31 doi: 10.16155/j.0254-1793.2024-0395
Outline
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Objective: To establish an ultra-high performance liquid chromatography tandem mass spectrometry（UPLC-MS/MS）method for the simultaneous determination of 22 components of Bimin capsules, including benzoylaconine, benzoylmesaconine, benzoylhypacoitine, hypaconitine, mesaconitine, fuziline, aconitine, aconine,mesaconine, isoliquiritigenin, echinatin, protocatechuic acid, liquiritigenin, isoliquiritoside, glycycoumarin,naringenin, schaftoside, licochalcone B, glycyrrhizic acid ammonium salt, liquiritin, liquiritin apioside and isoliquiritin apioside. Methods: The AcclaimTM RSLC 120C18 column (2.1 mm×100 mm, 2.2 μm) was used with 0.05% formic acid water (A) and acetonitrile (B) as the mobile phase at a flow rate of 0.4 mL · min-1. Electrospray ionization (ESI) source and multiple reaction monitoring (MRM) mode in both positive and negative were used for ion detections. Resulets:The 22 components displayed a good linear relationship (R2>0.990) in their respective ranges, and the precision, repeatability, stability, and sample recovery rate all met the requirements. It was found that all 22 components were detected in the nasal sensitivity capsules, with significant differences in the content of some components. Conclusion: This method is fast, simple, sensitive and reliable, and can provide scientific basis for the quality control of the Bimin capsules.

Bimin capsules  /  chemical composition  /  UPLC-MS/MS  /  content determination  /  allergic rhinitis
Lei CAO, Jian-yun BI, Yu-qing WANG, Xin-jun ZHANG, Ming SU, Bo-yang WANG, Xin-rui LI, Xin-ru SUN, Kang-ning XIAO, Yu-jie HOU, Sheng-mei LIU, Qian ZHOU, Shan-xin LIU. Simultaneou determination of 22 components in Bimin capsules by UPLC-MS/MS*[J]. Chinese Journal of Pharmaceutical Analysis, 2025 , 45 (3) : 400 -408 . DOI: 10.16155/j.0254-1793.2024-0395
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Year 2025 volume 45 Issue 3
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Article Info
doi: 10.16155/j.0254-1793.2024-0395
  • Receive Date：2024-06-14
  • Online Date：2026-03-17
  • Published：2025-03-31
Article Data
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History
  • Received：2024-06-14
Funding
Affiliations
    1. Shandong University of Chinese Medicine, Jinan 250355, China
    2. Shandong Academy of Traditional Chinese Medicine,Jinan 250014, China
    3. Shandong Kangzhonghong Pharmaceutical Technology Development Co., Ltd, Jinan, 250061, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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