PDF
Full
Outline
Gas chromatography-Orbitrap mass spectrometry (GC-Orbitrap/MS), a developing gas chromatography-high resolution mass spectrometry approach, allows for high throughput qualitative and quantitative analysis of volatile and semi-volatile components. It has the advantages of high sensitivity, selectivity, and a wide linear dynamic range, which makes it well suitable for the analysis of a wide range of trace substances in complex matrices. In recent years, this technology has been applied in environmental science, industry, food analysis, pharmaceutical analysis, forensic science, clinical medicine and other fields. This paper presents the first review of GC-Orbitrap/MS, which not only describes the basic principles and technical characteristics, but also introduces the progress of the technique in food and pharmaceutical research. Applications in food analysis include the inspection of pesticide residues, detection of persistent organic compounds and analysis of flavor substances. In pharmaceutics, the analysis of chemical impurities and quality evaluation of traditional Chinese medicine are introduced. It is noteworthy that this technique is particularly advantageous for the identification of unknown compounds and the determination of ultra-trace components. Lastly but importantly, this review summarizes the challenges encountered in the current development of this technique, including the establishment of high-resolution standard databases, the selection and optimization of sample pre-treatment method and the application of GC-Orbitrap/MS in the field of traditional traditional Chinese medicine. A few solutions are also proposed, such as the application of variable electron voltage technique, the combination of two-dimensional gas chromatography and electrostatic field Orbitrap mass spectrometry and the integrated analysis comprehensively using multiple scan modes. These strategies are aimed to provide more advanced and accurate solutions to food, pharmaceutical, and other relevant analysis.
PDF
88
37
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
