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To develop a method for the determination of meropenem and vaborbactam for injection by HPLC.
The chromatography was performed on Shimadzu InertSustain C18 (150 mm×4.6 mm，5 μm) column with acetonitrile-0.02 mol·L-1 sodium dihydrogen phosphate solution (adjust pH to 2.8 with phosphoric acid)(10：90) as a mobile phase，the flow rate was 1.0 mL·min-1，the detection wavelength was 210 nm，and the sample volume was 10 μL. A method for the determination of meropenem and vaborbactam for injection was established under the chromatographic conditions.
In this method，the linearities of meropenem and vaborbactam were good，and the linearity ranges were 21.40-214.0 μg·mL-1 and 19.83-198.3 μg·mL-1. Meropenem and vaborbactam had good precision with RSD of 0.31% and 0.16%，respectively. Within 24 h，meropenem and vaborbactam had good stabilities at 4 ℃，RSDs were 0.31% and 0.16%，respectively. The average recoveries of meropenem and vaborbactam were 101.0% (n=9) and 98.4% (n=9) (RSD<2.0%). The contents of meropenem and vaborbactam were 405.8 mg·g-1 and 399.1 mg·g-1，respectively.
The method is accurate，simple and rapid，and can be used for the determination of meropenem and vaborbactam for injection.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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