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To establish an ion chromatography method suitable for simultaneous determination of acid radical content in chemical reference substances containing methanesulfonic acid，hydrochloric acid，phosphoric acid，sulfuric acid and butadisulfonic acid.
The chromatographic column of Metrosep A Supp 5 250/4.0 (250 mm×4.0 mm，5 μm) was used with 6.4 mmol·L-1 Na2CO3 and 2.0 mmol·L-1 NaHCO3 as the eluent with a flow rate of 0.7 mL·min-1. Column temperature was 30 ℃.
Methanesulfonate (19.1-71.7 μg·mL-1)，chloride ion (2.6-25.8 μg·mL-1)，phosphate (7.0-26.3 μg·mL-1)，sulfate (6.8-51.0 μg·mL-1)，and succinate (21.3-105.5 μg·mL-1) had good linear relationships within their respective ranges (r≥0.999 5). Precision (RSD≤2%)，stability (RSD≤2%) and repeatability (RSD≤2%) were good. The average recovery rates (n=9) were 98%-102%. Calculated as salt formation，the content of mesylate in amlodipine mesylate was 23.69%，the content of hydrochloric acid in guanfacine hydrochloride was 12.66%，the content of phosphoric acid in reagliptin phosphate was 17.38%，the content of sulphate in salbutamol sulfate was 16.49%，and the content of butyldisulfonic acid in adenosine butyldisulfonic acid was 45.61%. The deviation between theoretical and measured values was less than 0.50%. The measured values were close to the theoretical values.
The method is suitable for the screen and determination of acid radicals in chemical reference products containing methanesulfonic acid，hydrochloric acid，phosphoric acid，sulfuric acid and butadisulfonic acid.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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