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To establish an HPLC method for the ratio of the enantiomer in fluralaner.
The chromatographic separation was performed on chiral chromatography column CHIRALPAK AD-H (250 mm×4.6 mm，5 μm). The mobile phase consisted of n-hexane-anhydrous ethanol (60：40) and the flow rate was 1.0 mL·min-1. The detection wavelength was 265 nm and the column temperature was room temperature.
Under this chromatographic condition，three batches of samples were determined，the proportions of R-fluralaner and S-fluralaner were 1：1. The calibration curves of R-fluralaner and S-fluralaner good linearities at the range of 80.288-187.338 μg·mL-1(r=0.999 7) and 81.902-191.104 μg·mL-1 (r=0.999 9)，respectively. The average recoveries were 100.6% and 100.8%.
The method is accurate，reproducible and can be used for the ratio of enantiomers in fluralaner racemate.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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