Home Journals Articles Updates About
CN
image
收藏切换
Determination and preliminary risk assessment of acrylamide in “8 famous medicines from Zhejiang” by isotope-labeled internal standard-UHPLC-MS/MS in combination with QuEChERS method*
收藏切换
PDF
Ying ZHOU1, Zhe XU3, Wen-ting ZHANG1, Yue-mei ZHOU2, Xiao-ying XU1, Wei-liang ZHAO2, Ying-ni PAN3, **, Cheng ZHENG1, **
Chinese Journal of Pharmaceutical Analysis | 2024, 44(6) : 1017 - 1023
Less
收藏切换
Chinese Journal of Pharmaceutical Analysis | 2024, 44(6): 1017-1023
• Safety Monitorin •
Determination and preliminary risk assessment of acrylamide in “8 famous medicines from Zhejiang” by isotope-labeled internal standard-UHPLC-MS/MS in combination with QuEChERS method*
Full
Ying ZHOU1, Zhe XU3, Wen-ting ZHANG1, Yue-mei ZHOU2, Xiao-ying XU1, Wei-liang ZHAO2, Ying-ni PAN3, **, Cheng ZHENG1, **
Affiliations
  • 1.Zhejiang Institute for Food and Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Hangzhou 310052, China
  • 2.Hangzhou Normal University, Hangzhou 311121, China
  • 3.Shenyang Pharmaceutical University, Shenyang 110000, China
Published: 2024-06-30 doi: 10.16155/j.0254-1793.2024.06.12
Outline
收藏切换
Objective:

To determine the content of acrylamide in “8 famous medicines from Zhejiang”, and to carry out the preliminary risk assessment based on the determination results.

Methods:

After optimization of QuEChERS extraction, the content of acrylamide was determined by the method of isotope-labeled internal standard-ultra high performance liquid chromatography-tandem mass spectrometry (isotope-labeled IS-UHPLC-MS/MS). The determination was carried out with a Phenomenex Kinetex C18 column (100 mm×2.1 mm, 1.7 μm) as the stationary phase, gradient elution was carried out with methanol-0.1% formic acid aqueous solution as the mobile phase, 13C3 acrylamide as the internal standard, and multiple reaction monitoring (MRM) mode was used to detect the residual acrylamide.

Results:

The content ranges of acrylamide in 247 batches of samples were 0-26 403 μg·kg-1. These contents exceeded the regulations stipulated by some nations or organizations, and posed certain safety risks in long-term use.

Conclusion:

The method established in this study is rapid, simple, sensitive and reproducible, and will lay a scientific basis for the quality control and safety evaluation of acrylamide in “8 famous medicines from Zhejiang” and other genuine medicinal materials.

acrylamide  /  8 famous medicines from Zhejiang  /  ultra high performance liquid chromatography-tandem mass spectrometry  /  content determination  /  risk assessment  /  QuEChERS
Ying ZHOU, Zhe XU, Wen-ting ZHANG, Yue-mei ZHOU, Xiao-ying XU, Wei-liang ZHAO, Ying-ni PAN, Cheng ZHENG. Determination and preliminary risk assessment of acrylamide in “8 famous medicines from Zhejiang” by isotope-labeled internal standard-UHPLC-MS/MS in combination with QuEChERS method*[J]. Chinese Journal of Pharmaceutical Analysis, 2024 , 44 (6) : 1017 -1023 . DOI: 10.16155/j.0254-1793.2024.06.12
Appendix
Less
Year 2024 volume 44 Issue 6
PDF
65
30
Cite this Article
BibTeX
Article Info
doi: 10.16155/j.0254-1793.2024.06.12
  • Receive Date：2023-08-17
  • Online Date：2026-03-13
  • Published：2024-06-30
Article Data
Affiliations
History
  • Received：2023-08-17
Funding
Affiliations
    1.Zhejiang Institute for Food and Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Hangzhou 310052, China
    2.Hangzhou Normal University, Hangzhou 311121, China
    3.Shenyang Pharmaceutical University, Shenyang 110000, China
References
Share
https://castjournals.cast.org.cn/joweb/ywfxzz/EN/10.16155/j.0254-1793.2024.06.12
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House