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To establish a simple and practical microbiological counting method suitable for sheet drug packaging materials by comparing the results of four sampling methods.
The samples of artificial contamination of sheet drug packaging materials were prepared by standard strain adding method. The surface microorganisms were collected by wiping method prescribed by national drug packaging container (material) standard, as well as by self-designed washing method, direct inoculation method and contact dish method. The corresponding recovery rate was calculated. The results of 4 sampling methods were analyzed by one way analysis of variance (ANOVA).
From high to low, the recovery rate was as follows: contact dish method, direct inoculation method, wiping method and washing method. There were significant differences in the recovery rates of contact dish method, wiping method and washing method (P<0.05). The recovery rate of contact dish method was slightly higher than that of direct inoculation method, but there was no significant difference between them (P>0.05). There was no significant difference in the recoveries of medicinal film, aluminum foil and hard sheet among the four methods (P>0.05).
The contact dish method is simple, sensitive and accurate, and can be used for the examination of the microbial limit counting method of sheet drug packaging materials.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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