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Analysis of metabolites of the main chemical components of Periploca forrestii in normal and rheumatoid arthritis rats’ plasma，urine and feces*
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Xiong-li ZHANG1, 2, Tao XIA1, 2, Lin ZHENG1, Ming-yan CHI2, Yue-ting LI1, Zi-peng GONG1, Yang JIN3, Ting LIU1, Yong HUANG1, **
Chinese Journal of Pharmaceutical Analysis | 2024, 44(4) : 594 - 602
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Chinese Journal of Pharmaceutical Analysis | 2024, 44(4): 594-602
• Metabolism Analysis •
Analysis of metabolites of the main chemical components of Periploca forrestii in normal and rheumatoid arthritis rats’ plasma，urine and feces*
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Xiong-li ZHANG1, 2, Tao XIA1, 2, Lin ZHENG1, Ming-yan CHI2, Yue-ting LI1, Zi-peng GONG1, Yang JIN3, Ting LIU1, Yong HUANG1, **
Affiliations
  • 1.Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Functions and Applications of Medicinal Plants, Guiyang 550004, China
  • 2.Guizhou Medical University of Pharmacy, Guiyang 550004, China
  • 3.Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang 550004, China
Published: 2024-04-30 doi: 10.16155/j.0254-1793.2024.04.06
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Objective:

To investigate the metabolites of Periploca forrestii in plasma, urine, and feces of normal and adjuvant arthritis（AA） rats, and explore the effect of rheumatoid arthritis（RA） on the metabolism of active components of P. forrestii.

Methods:

AA rat model was made by means of Freund’s complete adjuvant. Plasma, urine and feces of normal and AA rats were analyzed by UPLC-Q-TOF-MSE method using ACQUITY UPLC BEH C18 (100 mm×2.1 mm, 1.7 μm) column with 0.01% formic acid water -0.01% formic acid acetonitrile as mobile phase gradient elution at a flow rate of 0.25 mL·min-1, and electrospray ion source under negative ion mode.

Results:

Two and three prototype components, 32 and 35 metabolites were detected in normal rats and AA model rats. The metabolic pathways mainly include monocaffeoylquinic acid reduction, methylation, ring-opening cleavage, glucuronidation, dicaffeoylquinic acid reduction, methylation, acetylation, isomerization, sulfation glucuronidation, etc.

Conclusion:

The metabolites in plasma and urine of AA model rats are more diverse than those in normal rats, and the disease state of RA may affect the metabolic pathway of effective components of P. forrestii in the body.

rheumatoid arthritis  /  Periploca forrestii Schltr. extract  /  monocaffeioylquinic acid  /  dicaffeoylquinic acid  /  metabolite  /  UPLC-Q TOF MSE  /  metabolic pathway
Xiong-li ZHANG, Tao XIA, Lin ZHENG, Ming-yan CHI, Yue-ting LI, Zi-peng GONG, Yang JIN, Ting LIU, Yong HUANG. Analysis of metabolites of the main chemical components of Periploca forrestii in normal and rheumatoid arthritis rats’ plasma，urine and feces*[J]. Chinese Journal of Pharmaceutical Analysis, 2024 , 44 (4) : 594 -602 . DOI: 10.16155/j.0254-1793.2024.04.06
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Year 2024 volume 44 Issue 4
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Article Info
doi: 10.16155/j.0254-1793.2024.04.06
  • Online Date：2026-03-13
  • Published：2024-04-30
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History
  • Revised：2024-03-02
Funding
Affiliations
    1.Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Functions and Applications of Medicinal Plants, Guiyang 550004, China
    2.Guizhou Medical University of Pharmacy, Guiyang 550004, China
    3.Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang 550004, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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