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Risk assessment of combined exposure to cadmium and arsenic in Isatidis Radix based on target-organ toxicity dose modification of HI method*
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Tian-tian ZUO1, Yong-li LIU2, Hong-yu JIN1, Hai-liang LI1, Yuan-xi LIU1, Jian-dong YU1, **, Shuang-cheng MA1, **
Chinese Journal of Pharmaceutical Analysis | 2024, 44(4) : 714 - 720
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Chinese Journal of Pharmaceutical Analysis | 2024, 44(4): 714-720
• Standard Deliberation •
Risk assessment of combined exposure to cadmium and arsenic in Isatidis Radix based on target-organ toxicity dose modification of HI method*
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Tian-tian ZUO1, Yong-li LIU2, Hong-yu JIN1, Hai-liang LI1, Yuan-xi LIU1, Jian-dong YU1, **, Shuang-cheng MA1, **
Affiliations
  • 1.National Institutes for Food and Drug Control, Beijing 102629, China
  • 2.The Pharmacovigilance Center of Hebei, Shijiazhuang 050090, China
Published: 2024-04-30 doi: 10.16155/j.0254-1793.2024.04.18
Outline
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Objective:

To determine the contents of Cd and As in Isatidis Radix and to explore the application of target-organ toxicity dose(TTD) modification of hazard index (HI) method in assessing the risk of combined exposure to heavy metals and harmful elements in traditional Chinese medicines (TCMs).

Methods:

According to the monitoring data of Cd and As in Isatidis Radix, the exposure doses were calculated. The health risk caused by combined exposure to Cd and As was preliminary screened by HI method. Moreover, a more accurate TTD method was used.

Results:

The qualified rates of Cd in 29 batches of Isatidis Radix were 100%. However, 5 batches of As contents exceeded the limit standard. The HQ values of As in 5 batches of Isatidis Radix were more than 1. The results of TTD method showed that for the end points of cardiovascular system, blood, nervous system, the HI values of 5 batches of Isatidis Radix were more than 1, and the health risk was not acceptable.

Conclusion:

The cumulative risk assessment of heavy metals in TCMs is proposed in this study, which offers novel ideas for the development of risk assessment methods of exogenous harmful residues in TCMs, and provides technical support for formulating scientific limit standards.

target-organ toxicity dose(TTD) modification of HI method  /  cadmium  /  arsenic  /  Isatidis Radix  /  combined exposure  /  cumulative risk assessment  /  traditional Chinese medicine
Tian-tian ZUO, Yong-li LIU, Hong-yu JIN, Hai-liang LI, Yuan-xi LIU, Jian-dong YU, Shuang-cheng MA. Risk assessment of combined exposure to cadmium and arsenic in Isatidis Radix based on target-organ toxicity dose modification of HI method*[J]. Chinese Journal of Pharmaceutical Analysis, 2024 , 44 (4) : 714 -720 . DOI: 10.16155/j.0254-1793.2024.04.18
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Year 2024 volume 44 Issue 4
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Article Info
doi: 10.16155/j.0254-1793.2024.04.18
  • Online Date：2026-03-13
  • Published：2024-04-30
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History
  • Revised：2024-03-26
Funding
Affiliations
    1.National Institutes for Food and Drug Control, Beijing 102629, China
    2.The Pharmacovigilance Center of Hebei, Shijiazhuang 050090, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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