To establish an inductively coupled plasma mass spectrometry (ICP-MS) method for the determination of migration Co，As，Br，Cd，Sb，Ba and Pb in recombinant human coagulation factor Ⅷ-Fc fusion protein for injection，and to quantitatively analyze the compatibility of long-term stored samples.

After adding 0.75 mL of water to the sample for 4 h，the purified water was filled to 5 mL，and the contents of 7 elements in the solution were determined by standard addition method. The working parameters of ICP-MS：radio frequency (RF) power of 1 550 W，sampling depth of 10.0 mm，carrier gas flow rate of 0.50 L·min^-1，atomizer pump speed of 0.30 r·s^-1，atomization chamber temperature of 2 ℃，dilution gas flow rate of 0.74 L·min^-1，repeated sampling times of 3 times，analysis mode of full quantitative.

The linear relationship of each element was good in the concentration range of the detected mass，and the recoveries of the element added were 92.0%-101.8%. When applied to the determination of the samples at each accelerated placement point，the increased migration amounts were 43.2，68.7 and 66.8 ng·mL^-1，respectively，except the element content of Br increased slightly. The contents of the remaining 6 elements were far below the prescribed limit.

The method is reliable and can be used for the determination of migration of 7 elements in recombinant human coagulation factor Ⅷ-Fc fusion protein for injection.