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To explore the minimum effective inhibitory concentration of bacteriostatic agent in the prescription of human interferon α1b spray, and to determine the reasonable dosage of bacteriostatic agent.
Biological activity detection method was used to screen bacteriostatic agents in the prescription of human interferon α1b spray preparation, determine bacteriostatic agents. The bacteriostatic efficacy was determined according to the bacteriostatic efficacy test method of general principles 1121 of the Chinese Pharmacopoeia 2020 edition to determine the minimum effective bacteriostatic concentration of bacteriostatic agents. Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger were used as test strains to test the applicability of colony counting method. The dose screening test of bacteriostatic agent was designed to investigate the bacteriostatic effect of bacteriostatic agent with different concentrations on four kinds of experimental bacteria, and the reasonable dosage of bacteriostatic agent was selected.
Benzalkonium bromide was screened out as the bacteriostatic agent in the prescription of human interferon α1b spray. When the concentration of Benzalkonium bromide was 0.05-0.1 mg·mL-1, its bacteriostatic efficacy against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger met the grade A criteria.
The minimum effective bacteriostatic concentration of benzalkonium bromide in the prescription of human interferon α1b spray is determined to be 0.05 mg·mL-1.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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