To establish an HPLC method for simultaneous determination of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, forsythiaside A, 3，4-O-dicaffeoylquinic acid, 3，5-O-dicaffeoylquinic acid, 4，5-O-dicaffeoylquinic acid, forsythin, andrographalide and dehydroandrographalide in compound Shuanghua tablets.

The samples were extracted with 50% methanol solution under ultrasonic condition, and were performed on Agilent Zoabax SB-C₁₈ column (250 mm×4.6 mm, 5 μm) by gradient elution of acetonitrile -0.15% phosphoric acid solution at a flow rate of 1.0 mL·min^-1. The column temperature was 30 ℃, the injection volume was 10 μL, and the detection wavelength were set at 327 nm (detecting neochlorogenic acid，chlorogenic acid, cryptochlorogenic acid, forsythiaside A，3，4-O-dicaffeoylquinic acid，3，5-O-dicaffeoylquinic acid and 4，5-O-dicaffeoylquinic acid) and 226 nm (detecting forsythin, andrographalide and dehydroandrographalide).

The linear ranges of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid，forsythiaside A，3，4-O-dicaffeoylquinic acid, 3，5-O-dicaffeoylquinic acid, 4，5-O-dicaffeoylquinic acid, forsythin, andrographalide and dehydroandrographalide were 4.071-40.71 μg·mL^-1(r=0.999 9), 20.16-201.6 μg·mL^-1(r=0.999 9), 4.730-47.30 μg·mL^-1(r=0.999 9), 4.536-45.36 μg·mL^-1(r=0.999 8), 1.817-18.17 μg·mL^-1(r=0.999 9), 2.266-22.66 μg·mL^-1(r=0.999 7), 3.321-33.21 μg·mL^-1(r=0.999 9), 3.462-34.62 μg·mL^-1(r=0.999 6), 2.111-21.11 μg·mL^-1(r=0.999 9) and 2.290-22.90 μg·mL^-1(r=0.999 7), respectively. The average recoveries (n=6) were 101.3%(2.1%)，103.0%(1.5%)，100.9%(2.0%)，101.1%(2.0%)，98.4%(1.6%)，102.2%(2.4%)，98.2%(1.3%)，97.8%(2.0%)，99.0%(2.0%) and 96.4%(1.1%), respectively. The contents of the 10 components in 4 bacthes of Fufang Shuanghua tablets were in the range of 1.685-2.649 mg·g^-1, 12.202-13.780 mg·g^-1, 2.415-2.594 mg·g^-1, 1.340-1.919 mg·g^-1, 0.501-0.791 mg·g^-1, 0.891-1.342 mg·g^-1, 1.299-2.105 mg·g^-1, 1.147-1.504 mg·g^-1, 0.654-0.694 mg·g^-1, 0.846-1.151 mg·g^-1, respectively.

This simple accurate reproducible method can be used for the quality control and evaluate of compound Shuanghua tablets.