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Consistency study on in vitro bioactivity of lactobacillin granules*
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Bo DING1, 2, Jun-zhen GUO1, Xiao-li MENG1, Wen-hong HU1, Xin-yong LIU2, **
Chinese Journal of Pharmaceutical Analysis | 2024, 44(2) : 272 - 279
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Chinese Journal of Pharmaceutical Analysis | 2024, 44(2): 272-279
• Bioassay·Activity Analysis •
Consistency study on in vitro bioactivity of lactobacillin granules*
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Bo DING1, 2, Jun-zhen GUO1, Xiao-li MENG1, Wen-hong HU1, Xin-yong LIU2, **
Affiliations
  • 1.Shandong Institute for Food and Drug Control, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Jinan 250101, China
  • 2.School of Pharmaceutical Sciences Shandong University, Jinan 250012, China
Published: 2024-02-29 doi: 10.16155/j.0254-1793.2024.02.10
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Objective:

To compare the in vitro bioactivity between a generic lactobacillin granules drug and three commercial lactobacillin granules drugs, this study investigated inhibition on pathogenic bacteria, the growth promoting effect on probiotics, and establish a method to evaluate the in vitro bioactivity consistency of drugs that regulate gut microbiota.

Methods:

Two culture systems were set up to investigate the inhibitory effect on pathogenic bacteria and the growth promoting effect on probiotics by lactobacillin granules. The in vitro bioactivity consistency of four products was evaluated by microbial growth curve and analyzed by two-way analysis of variance with Dunnett-t test.

Results:

No significant difference (P>0.05) was observed on inhibition of Staphylococcus aureus and growth promotion of Lactobacillus rhamnosus between the generic lactobacillin granules and the commercial lactobacillin granules.

Conclusion:

This method could be used to evaluate the in vitro bioactivity of drugs that regulate gut microbiota, and provided guidance on relevant drug development and quality evaluation.

lactobacillin granule  /  in vitro bioactivity  /  growth promoting test in vitro  /  in vitro bacteriostatic test  /  consistency evaluation
Bo DING, Jun-zhen GUO, Xiao-li MENG, Wen-hong HU, Xin-yong LIU. Consistency study on in vitro bioactivity of lactobacillin granules*[J]. Chinese Journal of Pharmaceutical Analysis, 2024 , 44 (2) : 272 -279 . DOI: 10.16155/j.0254-1793.2024.02.10
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Year 2024 volume 44 Issue 2
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Article Info
doi: 10.16155/j.0254-1793.2024.02.10
  • Online Date：2026-03-13
  • Published：2024-02-29
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History
  • Revised：2023-10-18
Funding
Affiliations
    1.Shandong Institute for Food and Drug Control, NMPA Key Laboratory for Research and Evaluation of Generic Drugs, Jinan 250101, China
    2.School of Pharmaceutical Sciences Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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