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CircRNAs are a large class of endogenous single-stranded RNAs that are different from other linear RNAs, which are produced by back-splicing and fusion of either exons, introns, or both exon-intron into covalently closed loops. They are widely expressed in highly differentiated eukaryotes, and are closely related to various development and metabolic disease processes of organisms. They are characterized by stable structure, resistant to RNA degradation, conservation, and tissue-specific expression, making them ideal biomarkers for diagnosis and prognosis. Traditional methods such as Northern blotting, qRT-PCR and microarray analysis provide useful information, however, they are subject to their own shortcomings. Traditional methods are restricted in large-scale promotion in clinical trials. In recent years, in order to solve these problems, some new detection methods have emerged. In this article, we reviewed the relevant progress of all current circRNA detection methods, expounded their advantages and limitations, and discussed the challenges and future development directions.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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