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Determination of dexzopiclone tablets content by quantitative nuclear magnetic resonance*
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Xiao-hong ZHENG1, Yi-hao CHE2, Zhi-hui XIAO1, **
Chinese Journal of Pharmaceutical Analysis | 2024, 44(3) : 380 - 385
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Chinese Journal of Pharmaceutical Analysis | 2024, 44(3): 380-385
• Ingredient Analys •
Determination of dexzopiclone tablets content by quantitative nuclear magnetic resonance*
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Xiao-hong ZHENG1, Yi-hao CHE2, Zhi-hui XIAO1, **
Affiliations
  • 1.Equipment Public Service Center of South China Sea Institute of Oceanology，Chinese Academy of Sciences，Guangzhou 510301，China
  • 2.Key Laboratory of Tropical Marine Bio-Resources and Ecology，South China Sea Institute of Oceanology，Chinese Academy of Sciences，Guangzhou 510301，China
Published: 2024-03-31 doi: 10.16155/j.0254-1793.2024.03.02
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Objective:

To establish a quantitative 1H-NMR (qHNMR) method for the determination of dexzopiclone tablets content.

Methods:

Proton signal at δ 6.08 of 1，3，5-trimethoxybenzene and δ 8.54，8.38，8.12，7.78 of dexzopiclone were served as the internal standard and quantitative peaks，respectively. DMSO-d6 was employed as the solvent. The qHNMR spectra were acquired at 298 K with 10 s relaxation delay and 32 scanning times.

Results:

The content of dexzopiclone was estimated to be 2.94% （RSD=0.15%）by qHNMR method，which indicated that 3.00 mg of dexzopiclone was in one tablet. The result was consistent with the description of the label.

Conclusion:

qHNMR method can be used to determine the content of dexzopiclone. The method is accurate，simple and efficient.

dexzopiclone  /  quantitative nuclear magnetic resonance  /  content determination  /  1，3，5-trimethoxybenzene
Xiao-hong ZHENG, Yi-hao CHE, Zhi-hui XIAO. Determination of dexzopiclone tablets content by quantitative nuclear magnetic resonance*[J]. Chinese Journal of Pharmaceutical Analysis, 2024 , 44 (3) : 380 -385 . DOI: 10.16155/j.0254-1793.2024.03.02
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Year 2024 volume 44 Issue 3
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Article Info
doi: 10.16155/j.0254-1793.2024.03.02
  • Receive Date：2023-07-26
  • Online Date：2026-03-13
  • Published：2024-03-31
Article Data
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History
  • Received：2023-07-26
Funding
Affiliations
    1.Equipment Public Service Center of South China Sea Institute of Oceanology，Chinese Academy of Sciences，Guangzhou 510301，China
    2.Key Laboratory of Tropical Marine Bio-Resources and Ecology，South China Sea Institute of Oceanology，Chinese Academy of Sciences，Guangzhou 510301，China
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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