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An overview of the application of in vivo small animal imaging technology in oncology research
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Yidan Zhou, Yuanyuan Lyu, Ximin Jin, Xingguang Liang*
Modern Instruments & Medical Treatment | 2025, 31(4) : 101 - 110
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收藏切换
Modern Instruments & Medical Treatment | 2025, 31(4): 101-110
An overview of the application of in vivo small animal imaging technology in oncology research
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Yidan Zhou, Yuanyuan Lyu, Ximin Jin, Xingguang Liang*
Affiliations
  • Central Laboratory, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
Published: 2025-08-10 doi: 10.11876/mimt202504011
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In vivo small animal imaging technology serves as a powerful tool for investigating tumor biology and evaluating anti-tumor therapeutic efficacy. This non-invasive modality enables real-time, dynamic observation of tumor initiation, progression, metastasis, and treatment response in living organisms, offering distinct advantages including visualizability, high spatiotemporal resolution, and exceptional sensitivity. Widely adopted in oncology research, this technology encompasses multimodal imaging approaches such as optical, nuclear medicine, and magnetic resonance imaging, each demonstrating unique characteristics and application scenarios. This article systematically summarizes three predominant in vivo small animal imaging techniques—optical 3D imaging, near-infrared fluorescence imaging, and 3D tomographic scanning, highlighting their respective technical advantages and application domains. Through presenting cutting-edge case studies in tumor mechanism research, metastasis monitoring, and therapeutic response assessment, this review aims to provide substantive references for advancing the application of in vivo small animal imaging in oncology research and anti-tumor treatment development.

Live imaging technology for small animals  /  Oncology research  /  Anti-tumor treatment  /  Visual observation  /  Application summary
周一丹, 吕媛媛, 金锡敏, 梁星光. 小动物活体成像技术在肿瘤研究领域的应用综述. 现代仪器与医疗, 2025 , 31 (4) : 101 -110 . DOI: 10.11876/mimt202504011
Yidan Zhou, Yuanyuan Lyu, Ximin Jin, Xingguang Liang. An overview of the application of in vivo small animal imaging technology in oncology research[J]. Modern Instruments & Medical Treatment, 2025 , 31 (4) : 101 -110 . DOI: 10.11876/mimt202504011
Year 2025 volume 31 Issue 4
61
9
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doi: 10.11876/mimt202504011
  • Online Date:2026-10-23
  • Published:2025-08-10
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    Central Laboratory, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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