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Outline
To investigate the alteration of brain regional homogeneity (ReHo) in Parkinson's disease (PD) patients with excessive daytime sleepiness (EDS) by resting-state functional MRI.
Total of 56 PD patients and age, gender and education level-matched 25 healthy controls underwent clinical assessments and resting-state functional magnetic resonance imaging (rs-fMRI). Patients were further divided into PD with EDS (n=27) and PD without EDS (n=29), according to the Epworth sleepiness scale (ESS). The data was processed by DPABI based on MATLAB. ANCOVA and post hoc two-sample t-tests were performed to examine between-groups differences of ReHo. Correlation analyses were performed between ReHo values of the regions showing group differences and ESS scores respectively.
Compared to the HC group, the ReHo values of the left superior temporal gyrus, left pallidum and left caudate in the PD with EDS group were decreased, while the right angular and right superior frontal gyrus were increased (P<0.05, FDR corrected). Compared to the PD without EDS group, the ReHo values of the left superior temporal gyrus in the PD with EDS group were decreased, while the left thalamus and left middle occipital gyrus were increased (P<0.05, FDR corrected). Additionally, ReHo values of the left superior temporal gyrus in the PD with EDS group differing brain regions was negatively correlated with ESS scores (r=-0.45, P<0.05).
There are abnormal brain activities of the basal ganglia region and dorsal attention network in PD with EDS, it is helpful to exlpain the neurophysiological mechanisms of PD with EDS.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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