Full
Outline
Super-resolution microscopy (SRM) technology exhibits enormous application potential in the early diagnosis and treatment of cancer, owing to its capability of achieving ultra-high-resolution imaging of cellular structures or small-molecule substances at the nanoscale and even single-molecule level. This article systematically introduces the imaging principles of several mainstream SRM technologies, summarizes the commonly used fluorescent probe types of different technologies and the characteristics and specific application scenarios of each probe. Then, it outlines the application cases of SRM in early cancer diagnosis by observing diagnostic targets related to carbohydrates, membrane proteins, and exosomes. This demonstrates its core application value in identifying molecular distribution, monitoring structural changes, and revealing early cancer characteristics. It further introduces the advantages and specific applications of SRM in treating cancer through monitoring the endocytosis of nanomedicines, enhancing the efficacy of photodynamic therapy, and clarifying the mechanism of drug resistance. Finally, it discusses and analyzes the current shortcomings of SRM in imaging speed, probe stability, and clinical applicability, and looks forward to future research directions, aiming to promote the further application of SRM in cancer precision diagnosis and treatment.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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