Full
Outline
With the intensification of population aging, Alzheimer's disease (AD), as the main type of dementia, has attracted increasing attention due to its high incidence and heavy disease burden. The pathogenesis of AD remains unclear, and existing drug therapies still face significant limitations in terms of efficacy, accessibility, and economic burden. Therefore, non-pharmacological interventions have become a research hotspot. Gamma rhythm, a neural oscillation at 30~100 Hz in the brain, is closely related to cognitive function, and its attenuation is an important feature of cognitive impairment in AD. Gamma rhythmic stimulation enhances brain gamma oscillations through neural entrainment, showing great potential in AD intervention. This study systematically retrieved relevant literature from China National Knowledge Infrastructure database and Web of Science Core Collection from January 1, 2015 to June 30, 2025. It reviewed the researches of gamma rhythmic stimulation in the treatment of AD. The results show that gamma rhythmic stimulation exerts neuroprotective and cognitive-improving effects through multiple pathways, such as reducing amyloid β-protein (Aβ) deposition and tau hyperphosphorylation. Among them, audiovisual combined multimodal stimulation has entered phase III clinical trials, with good safety and compliance in home-based interventions. However, several key issues remain to be addressed in this field, including inconsistent stimulation parameters, incompletely clarified mechanisms, insufficient reproducibility of clinical effects, and lack of a standardized verification system. In the future, it is necessary to establish a neural entrainment verification standard based on electroencephalography/quantitative electroencephalography (EEG/qEEG), standardize stimulation parameters, develop precise and wearable closed-loop devices, promote multimodal synergistic interventions, and deepen research on molecular and circuit mechanisms. These efforts will accelerate the translational application of gamma rhythmic stimulation from basic research to standardized clinical practice for AD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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